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Within amygdala : basolateral parts are selectively impaired in premature-born adults
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Schmitz-Koep, Benita, Zimmermann, Juliana, Menegaux, Aurore, Nuttall, Rachel, Bäuml, Josef G., Schneider, Sebastian C., Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Wolke, Dieter, Bartmann, Peter, Hedderich, Dennis M. and Sorg, Christian (2021) Within amygdala : basolateral parts are selectively impaired in premature-born adults. NeuroImage: Clinical, 31 . 102780. doi:10.1016/j.nicl.2021.102780 ISSN 2213-1582.
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WRAP-Within-amygdala-basolateral-selectively-impaired-premature-born-adults-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2650Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.nicl.2021.102780
Abstract
While it is known that whole amygdala volume is lastingly reduced after premature birth, it is unknown whether different amygdala nuclei are distinctively affected by prematurity. This question is motivated by two points: First, the observation that developmental trajectories of superficial, centromedial and basolateral amygdala nuclei are different. And second, the expectation that these different developmental pathways are distinctively affected by prematurity. Furthermore, we stated the question whether alterations in amygdala nuclei are associated with increased adults’ anxiety traits after premature birth.
We investigated 101 very premature-born adults (<32 weeks of gestation and/or birth weight below 1500 g) and 108 full-term controls of a prospectively and longitudinally collected cohort at 26 years of age using automated amygdala nuclei segmentation based on structural MRI.
We found selectively reduced volumes of bilateral accessory basal nuclei (pertaining to the basolateral amygdala of claustral developmental trajectory) adjusted for whole amygdala volume. Volumes of bilateral accessory basal nuclei were positively associated with gestational age and negatively associated with duration of ventilation. Furthermore, structural covariance within the basolateral amygdala was increased in premature-born adults. We did not find an association between reduced volumes of basolateral amygdala and increased social anxiety in the prematurity group.
These results demonstrate specifically altered basolateral amygdala structure in premature-born adults. Data suggest that prematurity has distinct effects on amygdala nuclei.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants , Brain -- Growth, Developmental neurobiology , Amygdaloid body, Nervous system -- Imaging, Magnetic resonance imaging, Social phobia | |||||||||||||||||||||
Journal or Publication Title: | NeuroImage: Clinical | |||||||||||||||||||||
Publisher: | Elsevier BV | |||||||||||||||||||||
ISSN: | 2213-1582 | |||||||||||||||||||||
Official Date: | 9 August 2021 | |||||||||||||||||||||
Dates: |
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Volume: | 31 | |||||||||||||||||||||
Article Number: | 102780 | |||||||||||||||||||||
DOI: | 10.1016/j.nicl.2021.102780 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 13 August 2021 | |||||||||||||||||||||
Date of first compliant Open Access: | 13 August 2021 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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