The Library
Assessing the impact of secondary structure and solvent accessibility on protein evolution
Tools
UNSPECIFIED (1998) Assessing the impact of secondary structure and solvent accessibility on protein evolution. GENETICS, 149 (1). pp. 445-458. ISSN 0016-6731.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Abstract
Empirically derived models of amino acid replacement are employed to study the association between various physical features of proteins and evolution. The strengths of these associations are statistically evaluated by applying the models of protein evolution to 11 diverse sets of protein sequences. Parametric bootstrap tests indicate that the solvent accessibility status of a site has a particularly strong association with the process of amino acid replacement that it experiences. Significant association between secondary structure environment and the amino acid replacement process is also observed. Careful description of the length distribution of secondary structure elements and of the organization of secondary structure and solvent accessibility along a protein did not always significantly improve the fit of the evolutionary models to the data sets that were analyzed. As indicated by the strength of the association of both solvent accessibility and secondary structure with amino acid replacement, the process of protein evolution-both above and below the species level-will not be well understood until the physical constraints that affect protein evolution are identified and characterized.
Item Type: | Journal Article | ||||
---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH426 Genetics | ||||
Journal or Publication Title: | GENETICS | ||||
Publisher: | GENETICS | ||||
ISSN: | 0016-6731 | ||||
Official Date: | May 1998 | ||||
Dates: |
|
||||
Volume: | 149 | ||||
Number: | 1 | ||||
Number of Pages: | 14 | ||||
Page Range: | pp. 445-458 | ||||
Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |