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Exploring how microbiome signatures change across inflammatory bowel disease conditions and disease locations
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Amos, Gregory C. A., Sergaki, Chrysi, Logan, Alastair, Iriarte, Rolland, Bannaga, Ayman, Chandrapalan, Subashini, Wellington, Elizabeth M. H., Rijpkema, Sjoerd and Arasaradnam, Ramesh P. (2021) Exploring how microbiome signatures change across inflammatory bowel disease conditions and disease locations. Scientific Reports, 11 (1). 18699. doi:10.1038/s41598-021-96942-z ISSN 2045-2322.
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WRAP-exploring-microbiome-signatures-inflammatory-bowel-disease-conditions-locations-Wellington-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1530Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-021-96942-z
Abstract
Understanding the variables that influence microbiome studies is critical for successful translational research. Inflammatory bowel disease (IBD) is a complex group of diseases that can present at multiple locations within the Gastrointestinal tract. Here, using the FAMISHED study cohort, we aimed to investigate the relationship between IBD condition, IBD disease location, and the microbiome. Signatures of the microbiome, including measures of diversity, taxonomy, and functionality, all significantly differed across the three different IBD conditions, Crohn’s disease (CD), ulcerative colitis (UC), and microscopic colitis (MC). Notably, when stratifying by disease location, patients with CD in the terminal ileum were more similar to healthy controls than patients with CD in the small bowel or colon, however no differences were observed at different disease locations across patients with UC. Change in taxonomic composition resulted in changes in function, with CD at each disease location, UC and MC all having unique functional dysbioses. CD patients in particular had deficiencies in Short-Chain Fatty Acid (SCFA) pathways. Our results demonstrate the complex relationship between IBD and the microbiome and highlight the need for consistent strategies for the stratification of clinical cohorts and downstream analysis to ensure results across microbiome studies and clinical trials are comparable.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QR Microbiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Inflammatory bowel diseases , Inflammatory bowel diseases -- Epidemiology, Inflammatory bowel diseases -- Pathogenesis, Inflammatory bowel diseases -- Etiology, Gastrointestinal system -- Microbiology | ||||||
| Journal or Publication Title: | Scientific Reports | ||||||
| Publisher: | Nature Publishing Group UK | ||||||
| ISSN: | 2045-2322 | ||||||
| Official Date: | 21 September 2021 | ||||||
| Dates: |
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| Volume: | 11 | ||||||
| Number: | 1 | ||||||
| Article Number: | 18699 | ||||||
| DOI: | 10.1038/s41598-021-96942-z | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 8 October 2021 | ||||||
| Date of first compliant Open Access: | 11 October 2021 | ||||||
| RIOXX Funder/Project Grant: |
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