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Costs and cost-effectiveness of user-testing of health professionals’ guidelines to reduce the frequency of intravenous medicines administration errors by nurses in the United Kingdom : a probabilistic model based on Voriconazole administration
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Jones, Matthew D., Franklin, Bryony Dean, Raynor, D. K., Thom, Howard, Watson, Margaret C. and Kandiyali, Rebecca (2022) Costs and cost-effectiveness of user-testing of health professionals’ guidelines to reduce the frequency of intravenous medicines administration errors by nurses in the United Kingdom : a probabilistic model based on Voriconazole administration. Applied Health Economics and Health Policy, 20 . pp. 91-104. doi:10.1007/s40258-021-00675-z ISSN 1175-5652.
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Official URL: http://dx.doi.org/10.1007/s40258-021-00675-z
Abstract
Aim
In the UK, injectable medicines are often prepared and administered by nurses following the Injectable Medicines Guide (IMG). Our earlier study confirmed a higher frequency of correct administration with user-tested versus standard IMG guidelines. This current study aimed to model the cost-effectiveness of user-testing.
Methods
The costs and cost-effectiveness of user-testing were explored by modifying an existing probabilistic decision-analytic model. The adapted model considered administration of intravenous voriconazole to hospital inpatients by nurses. It included 11 error types, their probability of detection and level of harm. Model inputs (including costs) were derived from our previous study and other published data. Monte Carlo simulation using 20,000 samples (sufficient for convergence) was performed with a 5-year time horizon from the perspective of the 121 NHS trusts and health boards that use the IMG. Sensitivity analyses were undertaken for the risk of a medication error and other sources of uncertainty.
Results
The net monetary benefit at £20,000/quality-adjusted life year was £3,190,064 (95% credible interval (CrI): −346,709 to 8,480,665), favouring user-testing with a 96% chance of cost-effectiveness. Incremental cost-savings were £240,943 (95% CrI 43,527–491,576), also favouring user-tested guidelines with a 99% chance of cost-saving. The total user testing cost was £6317 (95% CrI 6012–6627). These findings were robust to assumptions about a range of input parameters, but greater uncertainty was seen with a lower medication error risk.
Conclusions
User-testing of injectable medicines guidelines is a low-cost intervention that is highly likely to be cost-effective, especially for high-risk medicines.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Applied Health Economics and Health Policy | ||||||||
Publisher: | Springer | ||||||||
ISSN: | 1175-5652 | ||||||||
Official Date: | January 2022 | ||||||||
Dates: |
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Volume: | 20 | ||||||||
Page Range: | pp. 91-104 | ||||||||
DOI: | 10.1007/s40258-021-00675-z | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 2 August 2023 | ||||||||
Date of first compliant Open Access: | 2 August 2023 | ||||||||
RIOXX Funder/Project Grant: |
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