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Assessing the construct validity and responsiveness of preference-based measures (PBMs) in cataract surgery patients
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Breheny, Katie, Hollingworth, William, Kandiyali, Rebecca, Dixon, Padraig, Loose, Abi, Craggs, Pippa, Grzeda, Mariusz and Sparrow, John (2020) Assessing the construct validity and responsiveness of preference-based measures (PBMs) in cataract surgery patients. Quality of Life Research, 29 (7). pp. 1935-1946. doi:10.1007/s11136-020-02443-3 ISSN 0962-9343.
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Official URL: http://dx.doi.org/10.1007/s11136-020-02443-3
Abstract
Purpose
The validity and responsiveness of the EQ-5D-3L in visual conditions has been questioned, inspiring development of a vision ‘bolt-on’ domain (EQ-5D-3L + VIS). Developments in preference-based measures (PBM) also includes the EQ-5D-5L and the ICECAP-O capability wellbeing measure. This study aimed to examine the construct validity and responsiveness of the EQ-5D-3L, EQ-5D-5L, EQ-5D-3L + VIS and ICECAP-O in cataract surgery patients for the first time, to inform choice of PBM for economic evaluation in this population.
Methods
The analyses used data from the UK Predict-CAT cataract surgery cohort study. PBMs and the Cat-PROM5 [a validated measure of cataract quality of life (QOL)] were completed before surgery and 4–8 weeks after. Construct validity was assessed using correlations and known-group differences evaluated using regression. Responsiveness was evaluated using effect sizes and analysis of variance to compare change scores between groups, defined by patient-reported and clinical outcomes.
Results
The sample comprised 1315 patients at baseline. No PBMs were associated with visual acuity and only the ICECAP-O (Spearman’s rs = − 0.35), EQ-5D-3L + VIS (rs = − 0.42) and EQ-5D-5L (Value Set for England rs = − 0.31) correlated at least moderately with the Cat-PROM5. Effect sizes of change were consistently largest for the EQ-5D-3L + VIS (range 0.34–0.41), followed by the ICECAP-O (range 0.20–0.34). Results indicated no improvement in responsiveness using the EQ-5D-5L (range 0.13–0.16) compared to the EQ-5D-3L (range 0.17–0.20).
Conclusions
Whilst no PBMs comprehensively demonstrated evidence of construct validity and responsiveness in cataract surgery patients, the ICECAP-O was the most responsive generic PBM to improvements in QOL. Surprisingly the EQ-5D-5L was not more responsive than the EQ-5D-3L in this setting.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Quality of Life Research | ||||||||
Publisher: | Springer | ||||||||
ISSN: | 0962-9343 | ||||||||
Official Date: | July 2020 | ||||||||
Dates: |
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Volume: | 29 | ||||||||
Number: | 7 | ||||||||
Page Range: | pp. 1935-1946 | ||||||||
DOI: | 10.1007/s11136-020-02443-3 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) |
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