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Characterizing the countrywide epidemic spread of influenza A(H1N1)pdm09 virus in Kenya between 2009 and 2018
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Owuor, D. Collins, de Laurent, Zaydah R., Kikwai, Gilbert K., Mayieka, Lillian M., Ochieng, Melvin, Müller, Nicola F., Otieno, Nancy A., Emukule, Gideon O., Hunsperger, Elizabeth A., Garten, Rebecca, Barnes, John R., Chaves, Sandra S., Nokes, D. James and Agoti, Charles N. (2021) Characterizing the countrywide epidemic spread of influenza A(H1N1)pdm09 virus in Kenya between 2009 and 2018. Viruses, 13 (10). e1956. doi:10.3390/v13101956 ISSN 1999-4915.
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Official URL: https://doi.org/10.3390/v13101956
Abstract
The spatiotemporal patterns of spread of influenza A(H1N1)pdm09 viruses on a countrywide scale are unclear in many tropical/subtropical regions mainly because spatiotemporally representative sequence data are lacking. We isolated, sequenced, and analyzed 383 A(H1N1)pdm09 viral genomes from hospitalized patients between 2009 and 2018 from seven locations across Kenya. Using these genomes and contemporaneously sampled global sequences, we characterized the spread of the virus in Kenya over several seasons using phylodynamic methods. The transmission dynamics of A(H1N1)pdm09 virus in Kenya were characterized by (i) multiple virus introductions into Kenya over the study period, although only a few of those introductions instigated local seasonal epidemics that then established local transmission clusters, (ii) persistence of transmission clusters over several epidemic seasons across the country, (iii) seasonal fluctuations in effective reproduction number (Re) associated with lower number of infections and seasonal fluctuations in relative genetic diversity after an initial rapid increase during the early pandemic phase, which broadly corresponded to epidemic peaks in the northern and southern hemispheres, (iv) high virus genetic diversity with greater frequency of seasonal fluctuations in 2009–2011 and 2018 and low virus genetic diversity with relatively weaker seasonal fluctuations in 2012–2017, and (v) virus spread across Kenya. Considerable influenza virus diversity circulated within Kenya, including persistent viral lineages that were unique to the country, which may have been capable of dissemination to other continents through a globally migrating virus population. Further knowledge of the viral lineages that circulate within understudied low-to-middle-income tropical and subtropical regions is required to understand the full diversity and global ecology of influenza viruses in humans and to inform vaccination strategies within these regions.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Influenza A Virus, H1N1 Subtype -- Kenya, Hemagglutinin, Influenza viruses -- Research | |||||||||||||||
| Journal or Publication Title: | Viruses | |||||||||||||||
| Publisher: | MDPI | |||||||||||||||
| ISSN: | 1999-4915 | |||||||||||||||
| Official Date: | 29 September 2021 | |||||||||||||||
| Dates: |
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| Volume: | 13 | |||||||||||||||
| Number: | 10 | |||||||||||||||
| Article Number: | e1956 | |||||||||||||||
| DOI: | 10.3390/v13101956 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 11 October 2021 | |||||||||||||||
| Date of first compliant Open Access: | 12 October 2021 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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