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The DREAM complex represses growth in response to DNA damage in Arabidopsis
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Lang, Lucas, Pettkó-Szandtner, Aladár, Tunçay Elbaşı, Hasibe, Takatsuka, Hirotomo, Nomoto, Yuji, Zaki, Ahmad, Dorokhov, Stefan, De Jaeger, Geert, Eeckhout, Dominique, Ito, Masaki, Magyar, Zoltán, Bögre, László, Heese, Maren and Schnittger, Arp (2021) The DREAM complex represses growth in response to DNA damage in Arabidopsis. Life Science Alliance, 4 (12). e202101141. doi:10.26508/lsa.202101141 ISSN 2575-1077.
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WRAP-The-DREAM-complex-represses-growth-response-DNA-damage-Arabidopsis-Zaki-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (4Mb) | Preview |
Official URL: https://doi.org/10.26508/lsa.202101141
Abstract
The DNA of all organisms is constantly damaged by physiological processes and environmental conditions. Upon persistent damage, plant growth and cell proliferation are reduced. Based on previous findings that RBR1, the only Arabidopsis homolog of the mammalian tumor suppressor gene retinoblastoma, plays a key role in the DNA damage response in plants, we unravel here the network of RBR1 interactors under DNA stress conditions. This led to the identification of homologs of every DREAM component in Arabidopsis, including previously not recognized homologs of LIN52. Interestingly, we also discovered NAC044, a mediator of DNA damage response in plants and close homolog of the major DNA damage regulator SOG1, to directly interact with RBR1 and the DREAM component LIN37B. Consistently, not only mutants in NAC044 but also the double mutant of the two LIN37 homologs and mutants for the DREAM component E2FB showed reduced sensitivities to DNA-damaging conditions. Our work indicates the existence of multiple DREAM complexes that work in conjunction with NAC044 to mediate growth arrest after DNA damage.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QK Botany |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Arabidopsis , DNA damage, Homology (Biology) , Gene expression | ||||||||||||||||||||||||||||||
Journal or Publication Title: | Life Science Alliance | ||||||||||||||||||||||||||||||
Publisher: | Life Science Alliance | ||||||||||||||||||||||||||||||
ISSN: | 2575-1077 | ||||||||||||||||||||||||||||||
Official Date: | 28 September 2021 | ||||||||||||||||||||||||||||||
Dates: |
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Volume: | 4 | ||||||||||||||||||||||||||||||
Number: | 12 | ||||||||||||||||||||||||||||||
Article Number: | e202101141 | ||||||||||||||||||||||||||||||
DOI: | 10.26508/lsa.202101141 | ||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||||||||
Date of first compliant deposit: | 27 October 2021 | ||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 1 November 2021 | ||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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