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Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood
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Rammos, Alexandros, Sullivan, Sarah A., Kounali, Daphne, Jones, Hannah J., Hammerton, Gemma, Hines, Lindsey A., Lewis, Glyn, Jones, Peter B., Cannon, Mary, Thompson, Andrew, Wolke, Dieter, Heron, Jon and Zammit, Stanley (2022) Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood. The British Journal of Psychiatry, 220 (6). pp. 330-338. doi:10.1192/bjp.2021.145 ISSN 0007-1250.
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WRAP-Precursors-correlates-transient-persistent-longitudinal-psychotic-childhood-adulthood-2021.pdf - Accepted Version - Requires a PDF viewer. Download (1173Kb) | Preview |
Official URL: http://dx.doi.org/10.1192/bjp.2021.145
Abstract
Background
Psychotic experiences are reported by 5–10% of young people, although only a minority persist and develop into psychotic disorders. It is unclear what characteristics differentiate those with transient psychotic experiences from those with persistent psychotic experiences that are more likely to be of clinical relevance.
Aims
To investigate how longitudinal profiles of psychotic experiences, created from assessments at three different time points, are influenced by early life and co-occurring factors.
Method
Using data from 8045 individuals from a birth cohort study, longitudinal profiles of psychotic experiences based on semi-structured interviews conducted at 12, 18 and 24 years were defined. Environmental, cognitive, psychopathological and genetic determinants of these profiles were investigated, along with concurrent changes in psychopathology and cognition.
Results
Following multiple imputations, the distribution of longitudinal profiles of psychotic experiences was none (65.7%), transient (24.1%), low-frequency persistent (8.4%) and high-frequency persistent (1.7%). Individuals with high-frequency persistent psychotic experiences were more likely to report traumatic experiences, other psychopathology, a more externalised locus of control, reduced emotional stability and conscientious personality traits in childhood, compared with those with transient psychotic experiences. These characteristics also differed between those who had any psychotic experiences and those who did not.
Conclusions
These findings indicate that the same risk factors are associated with incidence as with persistence of psychotic experiences. Thus, it might be that the severity of exposure, rather than the presence of specific disease-modifying factors, is most likely to determine whether psychotic experiences are transient or persist, and potentially develop into a clinical disorder over time.
Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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Subjects: | R Medicine > RJ Pediatrics | ||||||||||||||||||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Psychoses in children -- Research, Psychoses in adolescence, Mental illness -- Diagnosis, Schizophrenia in children, Schizophrenia in adolescence, Adolescent psychopathology | ||||||||||||||||||||||||||||||
Journal or Publication Title: | The British Journal of Psychiatry | ||||||||||||||||||||||||||||||
Publisher: | Royal College of Psychiatrists | ||||||||||||||||||||||||||||||
ISSN: | 0007-1250 | ||||||||||||||||||||||||||||||
Official Date: | June 2022 | ||||||||||||||||||||||||||||||
Dates: |
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Volume: | 220 | ||||||||||||||||||||||||||||||
Number: | 6 | ||||||||||||||||||||||||||||||
Page Range: | pp. 330-338 | ||||||||||||||||||||||||||||||
DOI: | 10.1192/bjp.2021.145 | ||||||||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This article has been published in a revised form in The British Journal of Psychiatry. http://doi.org/10.1192/bjp.2021.145. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. © copyright holder. | ||||||||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||
Copyright Holders: | Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists | ||||||||||||||||||||||||||||||
Date of first compliant deposit: | 12 October 2021 | ||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 6 April 2022 | ||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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