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Asymmetric transfer hydrogenation of α-Keto amides ; highly enantioselective formation of malic acid diamides and α-Hydroxyamides
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Gediya, Shweta K., Vyas, Vijyesh K., Clarkson, Guy J. and Wills, Martin (2021) Asymmetric transfer hydrogenation of α-Keto amides ; highly enantioselective formation of malic acid diamides and α-Hydroxyamides. Organic Letters, 23 (20). pp. 7803-7807. doi:10.1021/acs.orglett.1c02830 ISSN 1523-7060.
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WRAP-Asymmetric-transfer-hydrogenation-ketoamides-highly-enantioselective-malic-acid-diamides-2021.pdf - Accepted Version - Requires a PDF viewer. Download (1406Kb) | Preview |
Official URL: https://doi.org/10.1021/acs.orglett.1c02830
Abstract
The asymmetric transfer hydrogenation (ATH) of α-keto-1,4-diamides using a tethered Ru/TsDPEN catalyst was achieved in high ee. Studies on derivatives identified the structural elements which lead to the highest enantioselectivities in the products. The α-keto-amide reduction products have been converted to a range of synthetically valuable derivatives.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Ketones, Catalysis, Asymmetric synthesis, Chemistry, Organic | |||||||||
Journal or Publication Title: | Organic Letters | |||||||||
Publisher: | American Chemical Society | |||||||||
ISSN: | 1523-7060 | |||||||||
Official Date: | 15 October 2021 | |||||||||
Dates: |
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Volume: | 23 | |||||||||
Number: | 20 | |||||||||
Page Range: | pp. 7803-7807 | |||||||||
DOI: | 10.1021/acs.orglett.1c02830 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see 10.1021/acs.orglett.1c02830 | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Copyright Holders: | Copyright © 2021 American Chemical Society | |||||||||
Date of first compliant deposit: | 19 October 2021 | |||||||||
Date of first compliant Open Access: | 29 September 2022 | |||||||||
RIOXX Funder/Project Grant: |
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