The Library
Reduced health-related quality of life in children born extremely preterm in 2006 compared with 1995 : the EPICure Studies
Tools
Ni, Yanyan, Johnson, Samantha, Marlow, Neil and Wolke, Dieter (2022) Reduced health-related quality of life in children born extremely preterm in 2006 compared with 1995 : the EPICure Studies. Archives of Disease in Childhood - Fetal and Neonatal Edition, 107 (4). pp. 408-413. doi:10.1136/archdischild-2021-322888 ISSN 1359-2998.
|
PDF
WRAP-Reduced-health-related-quality-life-children-born-preterm-2006-1995-EPICure-studies-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (928Kb) | Preview |
Official URL: http://dx.doi.org/10.1136/archdischild-2021-322888
Abstract
Objective
To compare health-related quality of life (HRQL) in childhood for extremely preterm (EP) births before 26 weeks of gestation in England in two eras: 1995 and 2006.
Design
Prospective cohort studies.
Setting
School or home-based assessments at 11 years of age.
Participants Available data for 88 EP children born before 26 weeks of gestation in 2006 (EPICure2) were compared with those of 140 born in England during 1995 (EPICure). To account for social secular trends, the comparison between eras was also made for term-born controls as reference.
Main outcome measures
HRQL was measured using the parent-completed Health Utilities Index (HUI) questionnaire with utility scores calculated using the HUI3 classification system. Eight attributes were assessed: vision, hearing, speech, ambulation, dexterity, emotion, cognition and pain.
Results
At 11 years, mean utility scores were significantly lower in EPICure2 (2006) than in EPICure (1995; Δ −0.12, 95% CI −0.20 to –0.04). The difference increased (Δ −0.27, 95% CI −0.41 to –0.12) after adjusting for significant perinatal and demographic differences between cohorts. Rates of suboptimal function were increased in EPICure2 for all eight attributes, but statistically significant differences were only found in speech (p=0.004) and dexterity (p=0.020). After excluding children with severe neurodevelopmental impairment, the adjusted difference between cohorts remained significant but attenuated (−0.14 (−0.26 to –0.01)). Mean utility scores for controls were similar between cohorts (Δ −0.01 (−0.04 to 0.02)).
Conclusions
Using parent report, there was a clinically significant decline in HRQL ratings for EP children over time. Areas contributing the most to the decline were speech and dexterity.
Item Type: | Journal Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > RJ Pediatrics |
||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||||||||||
Library of Congress Subject Headings (LCSH): | Premature infants , Premature infants -- Development, Premature infants -- Diseases, Premature infants -- Growth , Premature infants -- Physiology , Quality of life | ||||||||||||
Journal or Publication Title: | Archives of Disease in Childhood - Fetal and Neonatal Edition | ||||||||||||
Publisher: | B M J Group | ||||||||||||
ISSN: | 1359-2998 | ||||||||||||
Official Date: | 17 June 2022 | ||||||||||||
Dates: |
|
||||||||||||
Volume: | 107 | ||||||||||||
Number: | 4 | ||||||||||||
Page Range: | pp. 408-413 | ||||||||||||
DOI: | 10.1136/archdischild-2021-322888 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 28 October 2021 | ||||||||||||
Date of first compliant Open Access: | 1 November 2021 | ||||||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year