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Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks
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Wang, Jiaxu, Zhang, Tong, Yu, Zhang, Tan, Wen Ting, Wen, Ming, Shen, Yang, Lambert, Finnlay, Huber, Roland G. and Wan, Yue (2021) Genome-wide RNA structure changes during human neurogenesis modulate gene regulatory networks. Molecular Cell, 81 (23). pp. 4942-4953. doi:10.1016/j.molcel.2021.09.027 ISSN 1097-2765.
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Official URL: https://doi.org/10.1016/j.molcel.2021.09.027
Abstract
The distribution, dynamics, and function of RNA structures in human development are under-explored. Here, we systematically assayed RNA structural dynamics and their relationship with gene expression, translation, and decay during human neurogenesis. We observed that the human ESC transcriptome is globally more structurally accessible than differentiated cells and undergoes extensive RNA structure changes, particularly in the 3' UTR. Additionally, RNA structure changes during differentiation are associated with translation and decay. We observed that RBP and miRNA binding is associated with RNA structural changes during early neuronal differentiation, and splicing is associated during later neuronal differentiation. Furthermore, our analysis suggests that RBPs are major factors in structure remodeling and co-regulate additional RBPs and miRNAs through structure. We demonstrated an example of this by showing that PUM2-induced structure changes on LIN28A enable miR-30 binding. This study deepens our understanding of the widespread and complex role of RNA-based gene regulation during human development.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Molecular Cell | ||||||||
Publisher: | Cell Press | ||||||||
ISSN: | 1097-2765 | ||||||||
Official Date: | 2 December 2021 | ||||||||
Dates: |
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Volume: | 81 | ||||||||
Number: | 23 | ||||||||
Page Range: | pp. 4942-4953 | ||||||||
DOI: | 10.1016/j.molcel.2021.09.027 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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