RSV GOLD collaborators (Including:
). (2021) Global respiratory syncytial virus–related infant community deaths. Clinical Infectious Diseases, 73 (Supplement 3). S229-S237. doi:10.1093/cid/ciab528 ISSN 1058-4838.Preview |
PDF
WRAP-Global-respiratory-syncytial-virus–related-infant-community-deaths-2021.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (6MB) | Preview |
Abstract
Background
Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized.
Methods
The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital.
Results
We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001).
Conclusions
We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
| Library of Congress Subject Headings (LCSH): | Respiratory syncytial virus , Respiratory syncytial virus -- Transmission, Respiratory infections , Respiratory infections in children , Infants -- Mortality -- Developing countries -- Prevention |
| Journal or Publication Title: | Clinical Infectious Diseases |
| Publisher: | University of Chicago Press |
| ISSN: | 1058-4838 |
| Official Date: | 2 September 2021 |
| Dates: | Date Event 2 September 2021 Published 2 September 2021 Accepted |
| Volume: | 73 |
| Number: | Supplement 3 |
| Page Range: | S229-S237 |
| DOI: | 10.1093/cid/ciab528 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Open Access (Creative Commons open licence) |
| Date of first compliant deposit: | 12 November 2021 |
| Date of first compliant Open Access: | 15 November 2021 |
| RIOXX Funder/Project Grant: | Project/Grant ID RIOXX Funder Name Funder ID |
| URI: | https://wrap.warwick.ac.uk/160176/ |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |