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SARS-CoV-2 transmissibility compared between variants of concern and vaccination status
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Wang, Liang, Didelot, Xavier, Bi, Yuhai and Gao, George F. (2022) SARS-CoV-2 transmissibility compared between variants of concern and vaccination status. Briefings in Bioinformatics, 23 (2). bbab594. doi:10.1093/bib/bbab594 ISSN 1467-5463.
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WRAP-SARS-CoV-2-transmissibility-compared-variants-vaccination-status-2022.pdf - Accepted Version - Requires a PDF viewer. Download (2362Kb) | Preview |
Official URL: http://dx.doi.org/10.1093/bib/bbab594
Abstract
Since the start of the SARS-CoV-2 pandemic in late 2019, several variants of concern (VOC) have been reported to have increased transmissibility. In addition, despite the progress of vaccination against SARS-CoV-2 worldwide, all vaccines currently in used are known to protect only partially from infection and onward transmission. We combined phylogenetic analysis with Bayesian inference under an epidemiological model to infer the reproduction number (Rt) and also trace person-to-person transmission. We examined the impact of phylogenetic uncertainty and sampling bias on the estimation. Our result indicated that lineage B had a significantly higher transmissibility than lineage A and contributed to the global pandemic to a large extent. In addition, although the transmissibility of VOCs is higher than other exponentially growing lineages, this difference is not very high. The probability of detecting onward transmission from patients infected with SARS-CoV-2 VOCs who had received at least one dose of vaccine was approximate 1.06% (3/284), which was slightly lower but not statistically significantly different from a probability of 1.21% (10/828) for unvaccinated individuals. In addition to VOCs, exponentially growing lineages in each country should also be account for when tailoring prevention and control strategies. One dose of vaccination could not efficiently prevent the onward transmission of SARS-CoV-2 VOCs. Consequently, nonpharmaceutical interventions (such as wearing masks and social distancing) should still be implemented in each country during the vaccination period.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history R Medicine > RA Public aspects of medicine |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | COVID-19 (Disease) -- Transmission, Coronavirus infections -- Transmission, COVID-19 (Disease) -- Treatment, Coronavirus infections -- Treatment, Phylogeny | ||||||||||||||||||||||||
Journal or Publication Title: | Briefings in Bioinformatics | ||||||||||||||||||||||||
Publisher: | Oxford University Press | ||||||||||||||||||||||||
ISSN: | 1467-5463 | ||||||||||||||||||||||||
Official Date: | March 2022 | ||||||||||||||||||||||||
Dates: |
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Volume: | 23 | ||||||||||||||||||||||||
Number: | 2 | ||||||||||||||||||||||||
Number of Pages: | 12 | ||||||||||||||||||||||||
Article Number: | bbab594 | ||||||||||||||||||||||||
DOI: | 10.1093/bib/bbab594 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in Briefings in Bioinformatics following peer review. The version of record Liang Wang, Xavier Didelot, Yuhai Bi, George F Gao, SARS-CoV-2 transmissibility compared between variants of concern and vaccination status, Briefings in Bioinformatics, 2022;, bbab594, is available online at: http://dx.doi.org/10.1093/bib/bbab594 | ||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
Date of first compliant deposit: | 28 January 2022 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 22 January 2023 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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