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Electrochemical estimations of the gold nanoparticle size effect on cysteine-gold oxidation
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Romanovskaia, Elena, Slovenský, Peter, Kalantarian, S. Marzieh, Laundry-Mottiar, Lila, Romanovski, Valentin, Halama, Maroš , Auinger, Michael and Hedberg, Yolanda S. (2022) Electrochemical estimations of the gold nanoparticle size effect on cysteine-gold oxidation. Journal of The Electrochemical Society, 169 (2). 021501. doi:10.1149/1945-7111/ac4bf8 ISSN 0013-4651.
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Official URL: https://doi.org/10.1149/1945-7111/ac4bf8
Abstract
Gold nanoparticles are interesting for nanobiomedical applications, such as for drug delivery and as diagnostic imaging contrast agents. However, their stability and reactivity in-vivo are influenced by their surface properties and size. Here, we investigate the electrochemical oxidation of differently sized citrate-coated gold nanoparticles in the presence and absence of L-cysteine, a thiol-containing amino acid with high binding affinity to gold. We found that smaller sized (5, 10 nm) gold nanoparticles were significantly more susceptible to electrochemical L-cysteine interactions and/or L-cysteine-facilitated gold oxidation than larger (20, 50 nm) sized gold nanoparticles, both for the same mass and nominal surface area, under the conditions investigated (pH 7.4, room temperature, stagnant solutions, and scan rates of 0.5 to 450 mV s−1). The electrochemical measurements of drop-casted gold nanoparticle suspensions on paraffin-impregnated graphite electrodes were susceptible to the quality of the electrode. Increased cycling resulted in irreversible oxidation and detachment/oxidation of gold into solution. Our results suggest that L-cysteine-gold interactions are stronger for smaller nanoparticles.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
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| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) | |||||||||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Gold -- Electric properties, Nanoparticles -- Electric properties, Oxidation, Cysteine | |||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Journal of The Electrochemical Society | |||||||||||||||||||||||||||||||||
| Publisher: | Electrochemical Society, Inc. | |||||||||||||||||||||||||||||||||
| ISSN: | 0013-4651 | |||||||||||||||||||||||||||||||||
| Official Date: | 4 February 2022 | |||||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 169 | |||||||||||||||||||||||||||||||||
| Number: | 2 | |||||||||||||||||||||||||||||||||
| Article Number: | 021501 | |||||||||||||||||||||||||||||||||
| DOI: | 10.1149/1945-7111/ac4bf8 | |||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 24 March 2022 | |||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 25 March 2022 | |||||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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