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Insights into cell classification based on combination of multiple cellular mechanical phenotypes by using machine learning algorithm
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Tian, Yanling, Lin, Wangjiang, Qu, Kaige, Wang, Zuobin and Zhu, Xinyao (2022) Insights into cell classification based on combination of multiple cellular mechanical phenotypes by using machine learning algorithm. Journal of the Mechanical Behavior of Biomedical Materials, 128 . 105097. doi:10.1016/j.jmbbm.2022.105097 ISSN 1751-6161.
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Official URL: https://doi.org/10.1016/j.jmbbm.2022.105097
Abstract
Although cellular elastic property (CEP, also known as cellular elastic modulus) has been frequently reported as a biomarker to distinguish some cancerous cells from their benign counterparts, it cannot be adopted as a universal hallmark to be applied to every kind cell. In the present study, we report that insignificant difference is observed between normal gastric cell and its cancer counterpart which is one of the common human malignancies, in terms of CEP statistical distribution. In this regard, we propose multiple cellular mechanical phenotypes (CMPs) to differentiate the above two cell types, which is realized by machine learning algorithm (MLA). The results show that the cellular classification effect proves better with more CMPs adopted, regardless of the exact MLA employed. Moreover, the MLA-based method remains effective if we add two more cell lines to the above two cell categories. Our study indicates that MLA-based cellular classification can potentially serve as an efficient and objective means to assist or even validate cancer prognostics.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Journal of the Mechanical Behavior of Biomedical Materials | ||||||||
Publisher: | Elsevier BV | ||||||||
ISSN: | 1751-6161 | ||||||||
Official Date: | April 2022 | ||||||||
Dates: |
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Volume: | 128 | ||||||||
Article Number: | 105097 | ||||||||
DOI: | 10.1016/j.jmbbm.2022.105097 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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