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Altered grey matter cortical and subcortical T1-weighted/T2-weighted ratio in premature-born adults
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Schmitz-Koep, Benita, Menegaux, Aurore, Gaser, Christian, Brandes, Elin, Schinz, David, Thalhammer, Melissa, Daamen, Marcel, Boecker, Henning, Zimmer, Claus, Priller, Josef, Wolke, Dieter, Bartmann, Peter, Sorg, Christian and Hedderich, Dennis M. (2023) Altered grey matter cortical and subcortical T1-weighted/T2-weighted ratio in premature-born adults. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 8 (5). pp. 495-504. doi:10.1016/j.bpsc.2022.02.013 ISSN 2451-9022.
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WRAP-Altered-grey-matter-cortical-subcortical-T1-weighted-T2-weighted-premature-born-adults-2022.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (10Mb) | Preview |
Official URL: https://doi.org/10.1016/j.bpsc.2022.02.013
Abstract
Background
Microscopic studies in newborns and animal models indicate impaired myelination after premature birth, particularly for cortical myelination; however, it remains unclear whether such myelination impairments last into adulthood and – if so – are relevant for impaired cognitive performance. It has been suggested that the ratio of T1w and T2w MRI signal intensity (T1w/T2w ratio) is a proxy for myelin content. We hypothesized altered grey matter (GM) T1w/T2w ratio in premature-born adults, which is associated with lower cognitive performance after premature birth.
Methods
We analyzed GM T1w/T2w ratio in 101 very premature-born adults (<32 weeks of gestation and/or birthweight <1500g, VP/VLBW) and 109 full-term controls at 26 years of age, controlled for voxel-wise volume alterations. Cognitive performance was assessed by verbal, performance, and full-scale intelligence quotient (IQ) using the Wechsler Adult Intelligence Scale.
Results
Significantly higher T1w/T2w ratio in VP/VLBW subjects was found bilaterally in widespread cortical areas, particularly in frontal, parietal and temporal cortices, and in putamen and pallidum. In these areas, T1w/T2w ratio was not related to birth variables such as gestational age, or IQ scores. In contrast, significantly lower T1w/T2w ratio in VP/VLBW subjects was found in bilateral clusters in superior temporal gyrus which was associated with birth weight in the VP/VLBW group. Furthermore, lower T1w/T2w ratio in left superior temporal gyrus was associated with lower full-scale and verbal IQ.
Conclusions
Results demonstrate GM T1w/T2w ratio alterations in premature-born adults and suggest altered GM myelination development after premature birth with lasting and functionally relevant effects into early adulthood.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Premature labor , Prematurely born children , Brain -- Growth, Myelination , Brain -- Imaging | ||||||||||||||||||||||||
| Journal or Publication Title: | Biological Psychiatry: Cognitive Neuroscience and Neuroimaging | ||||||||||||||||||||||||
| Publisher: | Elsevier | ||||||||||||||||||||||||
| ISSN: | 2451-9022 | ||||||||||||||||||||||||
| Official Date: | May 2023 | ||||||||||||||||||||||||
| Dates: |
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| Volume: | 8 | ||||||||||||||||||||||||
| Number: | 5 | ||||||||||||||||||||||||
| Page Range: | pp. 495-504 | ||||||||||||||||||||||||
| DOI: | 10.1016/j.bpsc.2022.02.013 | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
| Date of first compliant deposit: | 24 March 2022 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 8 March 2023 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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