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Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo
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Huang, Ching-I, Crump, Ronald E., Brown, Paul E., Spencer, Simon E. F., Mwamba Miaka, Erick, Shampa, Chansy, Keeling, Matthew James and Rock, Kat S. (2022) Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo. Nature Communications, 13 (1). 1448. doi:10.1038/s41467-022-29192-w ISSN 2041-1723.
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Official URL: https://doi.org/10.1038/s41467-022-29192-w
Abstract
Gambiense human African trypanosomiasis (sleeping sickness, gHAT) is a disease targeted for elimination of transmission by 2030. While annual new cases are at a historical minimum, the likelihood of achieving the target is unknown. We utilised modelling to study the impacts of four strategies using currently available interventions, including active and passive screening and vector control, on disease burden and transmission across 168 endemic health zones in the Democratic Republic of the Congo. Median projected years of elimination of transmission show only 98 health zones are on track despite significant reduction in disease burden under medical-only strategies (64 health zones if > 90% certainty required). Blanket coverage with vector control is impractical, but is predicted to reach the target in all heath zones. Utilising projected disease burden under the uniform medical-only strategy, we provide a priority list of health zones for consideration for supplementary vector control alongside medical interventions.
| Item Type: | Journal Article | |||||||||||||||||||||
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| Subjects: | Q Science > QA Mathematics R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | African trypanosomiasis -- Congo (Democratic Republic), African trypanosomiasis -- Mathematical models, African trypanosomiasis -- Prevention , African trypanosomiasis -- Treatment, Communicable diseases -- Prevention -- Congo (Democratic Republic) | |||||||||||||||||||||
| Journal or Publication Title: | Nature Communications | |||||||||||||||||||||
| Publisher: | Nature Publishing Group | |||||||||||||||||||||
| ISSN: | 2041-1723 | |||||||||||||||||||||
| Official Date: | 18 March 2022 | |||||||||||||||||||||
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| Volume: | 13 | |||||||||||||||||||||
| Number: | 1 | |||||||||||||||||||||
| Article Number: | 1448 | |||||||||||||||||||||
| DOI: | 10.1038/s41467-022-29192-w | |||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
| Date of first compliant deposit: | 22 March 2022 | |||||||||||||||||||||
| Date of first compliant Open Access: | 22 March 2022 | |||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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