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Cell division in tissues enables macrophage infiltration
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Akhmanova, Maria, Emtenani, Shamsi, Krueger, Daniel, Gyoergy, Attila, Guarda, Mariana, Vlasov, Mikhail, Vlasov, Fedor, Akopian, Andrei, Ratheesh, Aparna, De Renzis, Stefano and Siekhaus, Daria E. (2022) Cell division in tissues enables macrophage infiltration. Science, 376 (6591). pp. 394-396. doi:10.1126/science.abj0425 ISSN 0036-8075.
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Official URL: https://doi.org/10.1126/science.abj0425
Abstract
Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Science | ||||||
Publisher: | American Association for the Advancement of Science | ||||||
ISSN: | 0036-8075 | ||||||
Official Date: | 22 April 2022 | ||||||
Dates: |
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Volume: | 376 | ||||||
Number: | 6591 | ||||||
Page Range: | pp. 394-396 | ||||||
DOI: | 10.1126/science.abj0425 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access |
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