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Focused update on stroke neuroimmunology : current progress in preclinical and clinical research and recent mechanistic insight
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Boltze, Johannes and Perez-Pinzon, Miguel A. (2022) Focused update on stroke neuroimmunology : current progress in preclinical and clinical research and recent mechanistic insight. Stroke, 53 (5). pp. 1432-1437. doi:10.1161/STROKEAHA.122.039005 ISSN 0039-2499.
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WRAP-Focused-stroke-neuroimmunology-preclinical-clinical-research-recent-mechanistic-2022.pdf - Accepted Version - Requires a PDF viewer. Download (329Kb) | Preview |
Official URL: http://dx.doi.org/10.1161/STROKEAHA.122.039005
Abstract
Local and systemic inflammation contribute significantly to stroke risk factors as well as determining stroke impact and outcome. Previously being considered as an immuno-privileged domain, the central nervous system is now recognized for multiple and complex interactions with the immune system in health and disease. The sterile inflammatory response emerging after ischemic stroke is a major pathophysiological hallmark and considered to be a promising therapeutic target. Even (mal)adaptive immune responses following stroke, potentially contributing to long-term impact and outcome, are increasingly discussed. However, the complex interaction between the central nervous and the immune system are only partially understood, placing neuroimmunological investigations at the forefront of preclinical and clinical research. This Focused Update summarizes current knowledge in stroke neuroimmunology across all relevant disciplines and discusses major advances as well as recent mechanistic insights. Specifically, neuroimmunological processes and neuroinflammation following ischemic are discussed in the context of blood-brain barrier dysfunction, microglia activation, thromboinflammation, and sex differences in poststroke neuroimmunological responses. The Focused Update further highlights advances in neuroimaging and experimental treatments to visualize and counter neuroinflammatory consequences of ischemic stroke.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QM Human anatomy Q Science > QP Physiology Q Science > QR Microbiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Immunity , Natural immunity, Blood-brain barrier , Cellular therapy , Cerebral ischemia , Neuroimmunology, Microglia , Nervous system -- Diseases, Sex differences , Stem cells, Cerebrovascular disease | ||||||||
| Journal or Publication Title: | Stroke | ||||||||
| Publisher: | Lippincott Williams & Wilkins | ||||||||
| ISSN: | 0039-2499 | ||||||||
| Official Date: | May 2022 | ||||||||
| Dates: |
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| Volume: | 53 | ||||||||
| Number: | 5 | ||||||||
| Page Range: | pp. 1432-1437 | ||||||||
| DOI: | 10.1161/STROKEAHA.122.039005 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | "This is a non-final version of an article published in final form in Boltze, Johannes and Perez-Pinzon, Miguel A. (2022) Focused update on stroke neuroimmunology : current progress in preclinical and clinical research and recent mechanistic insight. Stroke, 53 (5). pp. 1432-1437. doi:10.1161/STROKEAHA.122.039005 | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Copyright Holders: | © 2022 American Heart Association, Inc. | ||||||||
| Date of first compliant deposit: | 3 May 2022 | ||||||||
| Date of first compliant Open Access: | 25 October 2022 |
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