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Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure
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Yang, Anyi, Rolls, Edmund T., Dong, Guiying, Du, Jingnan, Li, Yuzhu, Feng, Jianfeng, Cheng, Wei and Zhao, Xing-Ming (2022) Longer screen time utilization is associated with the polygenic risk for Attention-deficit/hyperactivity disorder with mediation by brain white matter microstructure. EBioMedicine, 80 . 104039. doi:10.1016/j.ebiom.2022.104039 ISSN 2352-3964.
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Official URL: https://doi.org/10.1016/j.ebiom.2022.104039
Abstract
Attention-deficit/hyperactivity disorder (ADHD) has been reported to be associated with longer screen time utilization (STU) at the behavioral level. However, whether there are shared neural links between ADHD symptoms and prolonged STU is not clear and has not been explored in a single large-scale dataset. Leveraging the genetics, neuroimaging and behavioral data of 11,000+ children aged 9-11 from the Adolescent Brain Cognitive Development cohort, this study investigates the associations between the polygenic risk and trait for ADHD, STU, and white matter microstructure through cross-sectionally and longitudinal analyses. Children with higher polygenic risk scores for ADHD tend to have longer STU and more severe ADHD symptoms. Fractional anisotropy (FA) values in several white matter tracts are negatively correlated with both the ADHD polygenic risk score and STU, including the inferior frontal-striatal tract, inferior frontal-occipital fasciculus, superior longitudinal fasciculus and corpus callosum. Most of these tracts are linked to visual-related functions. Longitudinal analyses indicate a directional effect of white matter microstructure on the ADHD scale, and a bi-directional effect between the ADHD scale and STU. Furthermore, reduction of FA in several white matter tracts mediates the association between the ADHD polygenic risk score and STU. These findings shed new light on the shared neural overlaps between ADHD symptoms and prolonged STU, and provide evidence that the polygenic risk for ADHD is related, via white matter microstructure and the ADHD trait, to STU. This study was mainly supported by NSFC and National Key R&D Program of China. [Abstract copyright: Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.]
Item Type: | Journal Article | |||||||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Attention-deficit-disordered children , Hyperactive children , Hyperactive children -- Behavior modification, Brain -- Imaging, Attention-deficit-disordered children -- Effect of technological innovations on | |||||||||
Journal or Publication Title: | EBioMedicine | |||||||||
Publisher: | Elsevier BV | |||||||||
ISSN: | 2352-3964 | |||||||||
Official Date: | 1 May 2022 | |||||||||
Dates: |
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Volume: | 80 | |||||||||
Article Number: | 104039 | |||||||||
DOI: | 10.1016/j.ebiom.2022.104039 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 8 September 2022 | |||||||||
Date of first compliant Open Access: | 8 September 2022 | |||||||||
RIOXX Funder/Project Grant: |
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