The Library
The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion
Tools
Tools
Tools
Introini, Viola, Marin-Menendez, Alejandro, Nettesheim, Guilherme, Lin, Yen-Chun, Kariuki, Silvia N., Smith, Adrian L., Jean, Letitia, Brewin, John N., Rees, David C., Cicuta, Pietro, Rayner, Julian C. and Penman, Bridget S. (2022) The erythrocyte membrane properties of beta thalassaemia heterozygotes and their consequences for Plasmodium falciparum invasion. Scientific Reports, 12 (1). 8934. doi:10.1038/s41598-022-12060-4 ISSN 2045-2322.
|
PDF
WRAP-erythrocyte-membrane-properties-beta-thalassaemia-heterozygotes-consequences-Plasmodium-falciparum-invasion-Penman-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2571Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-022-12060-4
Abstract
Malaria parasites such as Plasmodium falciparum have exerted formidable selective pressures on the human genome. Of the human genetic variants associated with malaria protection, beta thalassaemia (a haemoglobinopathy) was the earliest to be associated with malaria prevalence. However, the malaria protective properties of beta thalassaemic erythrocytes remain unclear. Here we studied the mechanics and surface protein expression of beta thalassaemia heterozygous erythrocytes, measured their susceptibility to P. falciparum invasion, and calculated the energy required for merozoites to invade them. We found invasion-relevant differences in beta thalassaemic cells versus matched controls, specifically: elevated membrane tension, reduced bending modulus, and higher levels of expression of the major invasion receptor basigin. However, these differences acted in opposition to each other with respect to their likely impact on invasion, and overall we did not observe beta thalassaemic cells to have lower P. falciparum invasion efficiency for any of the strains tested.
| Item Type: | Journal Article | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QR Microbiology R Medicine > RC Internal medicine |
||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Mathematics | ||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Malaria -- Pathogenesis, Plasmodium falciparum, Host-parasite relationships, Thalassemia, Hemoglobinopathy -- Diagnosis | ||||||||||||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||||||||||||
| Publisher: | Nature Publishing Group UK | ||||||||||||||||||
| ISSN: | 2045-2322 | ||||||||||||||||||
| Official Date: | 27 May 2022 | ||||||||||||||||||
| Dates: |
|
||||||||||||||||||
| Volume: | 12 | ||||||||||||||||||
| Number: | 1 | ||||||||||||||||||
| Article Number: | 8934 | ||||||||||||||||||
| DOI: | 10.1038/s41598-022-12060-4 | ||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
| Date of first compliant deposit: | 6 June 2022 | ||||||||||||||||||
| Date of first compliant Open Access: | 7 June 2022 | ||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
