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Tran, Quy Don, Tran, Vienna, Toh, Li Shean, Williams, Philip M., Tran, Nam Nghiep and Hessel, Volker (2022) Space medicines for space health. ACS Medicinal Chemistry Letters, 13 (8). pp. 1231-1247. doi:10.1021/acsmedchemlett.1c00681 ISSN 1948-5875.
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WRAP-Space-medicines-space-health-2022.pdf - Accepted Version - Requires a PDF viewer. Download (1371Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acsmedchemlett.1c00681
Abstract
Scientists from around the world are studying the effects of microgravity and cosmic radiation via the “off-Earth” International Space Station (ISS) laboratory platform. The ISS has helped scientists make discoveries that go beyond the basic understanding of Earth. Over 300 medical experiments have been performed to date, with the goal of extending the knowledge gained for the benefit of humanity. This paper gives an overview of these numerous space medical findings, critically identifies challenges and gaps, and puts the achievements into perspective toward long-term space traveling and also adding benefits to our home planet. The medical contents are trifold structured, starting with the well-being of space travelers (astronaut health studies), followed by medical formulation research under space conditions, and then concluding with a blueprint for space pharmaceutical manufacturing. The review covers essential elements of our Earth-based pharmaceutical research such as drug discovery, drug and formulation stability, drug–organ interaction, drug disintegration/bioavailability/pharmacokinetics, pathogen virulence, genome mutation, and body’s resistance. The information compiles clinical, medicinal, biological, and chemical research as well as fundamentals and practical applications.
Item Type: | Journal Article | ||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine T Technology > TL Motor vehicles. Aeronautics. Astronautics |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||||
Library of Congress Subject Headings (LCSH): | Space medicine , Space stations -- Health aspects, Space flight -- Physiological effect, Astronauts -- Health risk assessment , Aviation medicine, Astronauts -- Health and hygiene | ||||||||||
Journal or Publication Title: | ACS Medicinal Chemistry Letters | ||||||||||
Publisher: | American Chemical Society | ||||||||||
ISSN: | 1948-5875 | ||||||||||
Official Date: | 11 August 2022 | ||||||||||
Dates: |
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Volume: | 13 | ||||||||||
Number: | 8 | ||||||||||
Number of Pages: | 17 | ||||||||||
Page Range: | pp. 1231-1247 | ||||||||||
DOI: | 10.1021/acsmedchemlett.1c00681 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Medicinal Chemistry Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acsmedchemlett.1c00681 | ||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||
Copyright Holders: | American Chemical Society | ||||||||||
Date of first compliant deposit: | 9 June 2022 | ||||||||||
Date of first compliant Open Access: | 28 April 2023 |
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