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Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division
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Bisson-Filho, Alexandre W., Hsu, Yen-Pang, Squyres, Georgia R., Kuru, Erkin, Wu, Fabai, Jukes, Calum, Sun, Yingjie, Dekker, Cees, Holden, Séamus, VanNieuwenhze, Michael S., Brun, Yves V. and Garner, Ethan C. (2017) Treadmilling by FtsZ filaments drives peptidoglycan synthesis and bacterial cell division. Science, 355 (6326). pp. 739-743. doi:10.1126/science.aak9973 ISSN 0036-8075.
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Official URL: http://dx.doi.org/10.1126/science.aak9973
Abstract
The mechanism by which bacteria divide is not well understood. Cell division is mediated by filaments of FtsZ and FtsA (FtsAZ) that recruit septal peptidoglycan-synthesizing enzymes to the division site. To understand how these components coordinate to divide cells, we visualized their movements relative to the dynamics of cell wall synthesis during cytokinesis. We found that the division septum was built at discrete sites that moved around the division plane. FtsAZ filaments treadmilled circumferentially around the division ring and drove the motions of the peptidoglycan-synthesizing enzymes. The FtsZ treadmilling rate controlled both the rate of peptidoglycan synthesis and cell division. Thus, FtsZ treadmilling guides the progressive insertion of new cell wall by building increasingly smaller concentric rings of peptidoglycan to divide the cell.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Science | ||||
Publisher: | American Association for the Advancement of Science | ||||
ISSN: | 0036-8075 | ||||
Official Date: | 17 February 2017 | ||||
Dates: |
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Volume: | 355 | ||||
Number: | 6326 | ||||
Page Range: | pp. 739-743 | ||||
DOI: | 10.1126/science.aak9973 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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