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Electrical signalling in prokaryotes and its convergence with quorum sensing in Bacillus
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Bavaharan, Abhirame and Skilbeck, Christopher (2022) Electrical signalling in prokaryotes and its convergence with quorum sensing in Bacillus. BioEssays, 44 (4). 2100193. doi:10.1002/bies.202100193
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WRAP-Electrical-signalling-in-prokaryotes-and-its-convergence-with-quorum-sensing-in-Bacillus-Bavaharan-22.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (898Kb) | Preview |
Official URL: http://dx.doi.org/10.1002/bies.202100193
Abstract
The importance of electrical signalling in bacteria is an emerging paradigm. Bacillus subtilis biofilms exhibit electrical communication that regulates metabolic activity and biofilm growth. Starving cells initiate oscillatory extracellular potassium signals that help even the distribution of nutrients within the biofilm and thus help regulate biofilm development. Quorum sensing also regulates biofilm growth and crucially there is convergence between electrical and quorum sensing signalling axes. This makes B. subtilis an interesting model for cell signalling research. SpoOF is predicted to act as a logic gate for signalling pathway convergence, raising interesting questions about the functional nature of this gate and the relative importance of these disparate signals on biofilm behaviour. How is an oscillating signal integrated with a quorum signal? The model presented offers rich opportunities for future experimental and theoretical modelling research. The importance of direct cell-to-cell electrical signalling in prokaryotes, so characteristic of multicellular eukaryotes, is also discussed.
Item Type: | Journal Item | ||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||||
Library of Congress Subject Headings (LCSH): | Biofilms , Prokaryotes , Quorum sensing (Microbiology) , Cellular signal transduction, Bacillus (Bacteria) | ||||||||||
Journal or Publication Title: | BioEssays | ||||||||||
Publisher: | John Wiley & Sons Ltd. | ||||||||||
ISSN: | 0265-9247 | ||||||||||
Official Date: | April 2022 | ||||||||||
Dates: |
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Volume: | 44 | ||||||||||
Number: | 4 | ||||||||||
Number of Pages: | 10 | ||||||||||
Article Number: | 2100193 | ||||||||||
DOI: | 10.1002/bies.202100193 | ||||||||||
Status: | Peer Reviewed | ||||||||||
Publication Status: | Published | ||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
Date of first compliant deposit: | 15 June 2022 | ||||||||||
Date of first compliant Open Access: | 16 June 2022 |
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