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POLY 433-site-specific conjugation of a well-defined functional poly(mPEG1100) methacrylate to salmon calcitonin : design, synthesis, characterization and investigation via NMR
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Randev, Rajan, Sayers, Claire, Ryan, Sinead, Mantovani, G. (Giuseppe), Keiper, Odin, Blindauer, Claudia A., Brayden, David J. and Haddleton, David M. (2008) POLY 433-site-specific conjugation of a well-defined functional poly(mPEG1100) methacrylate to salmon calcitonin : design, synthesis, characterization and investigation via NMR. In: 236th National Meeting of the American-Chemical-Society, Philadelphia, PA, 17-21 Aug 2008. Published in: Abstracts of papers of the American Chemical Society, Vol.236 433-POLY. ISSN 0065-7727.
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Abstract
The therapeutic value and nature of bio-molecules has been identified and exploited in numerous ways for several years. Conjugation of bio-molecules with synthetic molecules/macromolecules is one method of extending their lifetime by inhibiting degradation and excretion from the body to enhance therapeutic activity. One such technique is ‘pegylation' a term which refers to the combination of functionalized poly(ethylene glycol) with an appropriate bio-molecule.
Commercially available, PEGylated drugs are in some cases a mixture of different positional isomers, the development of further generations of polymer therapeutic requires the design of site-specific conjugation strategies. Knowledge of the site of attachment will ensure both conjugation reproducibility and a better understanding of the bioconjugate structure/activity relationship.
In this present work, the possibility of employing such end functional macromolecules for the targeting of the N-terminus of a biologically relevant peptide, salmon calcitonin was explored. The resultant polymer bio-conjugate was investigated by NMR and biological assays.
Item Type: | Conference Item (Paper) | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Biomolecules -- Therapeutic use, Polymers -- Therapeutic use, Bioconjugates, Nuclear magnetic resonance | ||||
Journal or Publication Title: | Abstracts of papers of the American Chemical Society | ||||
Publisher: | American Chemical Society | ||||
ISSN: | 0065-7727 | ||||
Official Date: | 17 August 2008 | ||||
Dates: |
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Volume: | Vol.236 | ||||
Number of Pages: | 1 | ||||
Page Range: | 433-POLY | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Conference Paper Type: | Paper | ||||
Title of Event: | 236th National Meeting of the American-Chemical-Society | ||||
Type of Event: | Conference | ||||
Location of Event: | Philadelphia, PA | ||||
Date(s) of Event: | 17-21 Aug 2008 |
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