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Degradable polyampholytes from radical ring-opening copolymerization enhance cellular cryopreservation
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Pesenti, Théo, Zhu, Chen, Gonzalez-Martinez, Natalia, Tomás, Ruben M. F., Gibson, Matthew I. and Nicolas, Julien (2022) Degradable polyampholytes from radical ring-opening copolymerization enhance cellular cryopreservation. ACS Macro Letters, 11 . pp. 889-894. doi:10.1021/acsmacrolett.2c00298 ISSN 2161-1653.
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WRAP-degradable-polyampholytes-radical-ring-opening-copolymerization-enhance-cellular-cryopreservation-Gibson-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3509Kb) | Preview |
Official URL: http://dx.doi.org/10.1021/acsmacrolett.2c00298
Abstract
Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Polyampholytes, Polymerization, Copolymers, Cells -- Cryopreservation | |||||||||||||||
Journal or Publication Title: | ACS Macro Letters | |||||||||||||||
Publisher: | American Chemical Society | |||||||||||||||
ISSN: | 2161-1653 | |||||||||||||||
Official Date: | 29 June 2022 | |||||||||||||||
Dates: |
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Volume: | 11 | |||||||||||||||
Page Range: | pp. 889-894 | |||||||||||||||
DOI: | 10.1021/acsmacrolett.2c00298 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 1 July 2022 | |||||||||||||||
Date of first compliant Open Access: | 1 July 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
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