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The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people : a national cohort study
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Maynou, Laia, Owen, Rhiannon, Konstant-Hambling, Rob, Imam, Towhid, Arkill, Suzanne, Bertfield, Deborah, Street, Andrew, Abrams, Keith R. and Conroy, Simon P. (2022) The association between frailty risk and COVID-19-associated all-mortality in hospitalised older people : a national cohort study. European Geriatric Medicine . 022. doi:10.1007/s41999-022-00668-8 ISSN 1878-7649.
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Official URL: https://doi.org/10.1007/s41999-022-00668-8
Abstract
Frailty has emerged as an important construct to support clinical decision-making during the COVID-19 pandemic. However, doubts remain related to methodological limitations of published studies. Retrospective cohort study of all people aged 75 + admitted to hospital in England between 1 March 2020 and 31 July 2021. COVID-19 and frailty risk were captured using International Classification of Disease-10 (ICD-10) diagnostic codes. We used the generalised gamma model to estimate accelerated failure time, reporting unadjusted and adjusted results. The cohort comprised 103,561 individuals, mean age 84.1, around half female, 82% were White British with a median of two comorbidities. Frailty risk was distributed approximately 20% low risk and 40% each at intermediate or high risk. In the unadjusted survival plots, 28-day mortality was almost 50% for those with an ICD-10 code of U071 (COVID-19 virus identified), and 25-35% for those with U072 (COVID-19 virus not identified). In the adjusted analysis, the accelerated failure time estimates for those with intermediate and high frailty risk were 0.63 (95% CI 0.58-0.68) and 0.67 (95% CI 0.62-0.72) fewer days alive respectively compared to those with low frailty risk with an ICD-10 diagnosis of U072 (reference category). In older people with confirmed COVID-19, both intermediate and high frailty risk were associated with reduced survival compared to those with low frailty risk.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RB Pathology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | COVID-19 (Disease), Frail elderly -- Health aspects, Hospital patients -- Mortality | ||||||
Journal or Publication Title: | European Geriatric Medicine | ||||||
Publisher: | Elsevier Ltd | ||||||
ISSN: | 1878-7649 | ||||||
Official Date: | 24 June 2022 | ||||||
Dates: |
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Article Number: | 022 | ||||||
DOI: | 10.1007/s41999-022-00668-8 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 8 September 2022 | ||||||
Date of first compliant Open Access: | 9 September 2022 | ||||||
RIOXX Funder/Project Grant: |
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