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Revisiting the effect of U-ends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor
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Cox, Rylan, Salonitis, Konstantinos, Rebrov, Evgeny V. and Impey, Susan A. (2022) Revisiting the effect of U-ends, flow parameters, and feasibility for scale-up on residence time distribution curves for a continuous bioprocessing oscillatory baffled flow reactor. Industrial & Engineering Chemistry Research, 61 (30). pp. 11181-11196. doi:10.1021/acs.iecr.2c00822 ISSN 0888-5885.
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Official URL: https://doi.org/10.1021/acs.iecr.2c00822
Abstract
An oscillatory baffled flow reactor (OBR) has been designed with 60 interbaffled cells. The baffled columns of 40 mm internal diameter together result in a reactor length of 5740 mm. The oscillatory amplitude and frequency were in the range of 2–12 mm and 0.3–2 Hz, respectively. The report investigates the impact of U-bends and the number of reactor sections on axial dispersion for scale-up feasibility. A prediction model using operating parameters has been developed to maximize plug flow conditions using the tanks-in-series (TiS) model. The maximum TiS value was 13.38 in a single column compared to 43.68 in the full reactor at a velocity ratio of 2.27 using oscillatory parameters 8 mm and 0.3 Hz. The mixing efficiency along the reactor was found to decrease after each column at amplitudes <6 mm compared to amplitudes up to 12 mm, where a negligible impact was observed. U-bend geometry had a significant role in the decrease of TiS values.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Oscillating chemical reactions , Chemical engineering , Chemical processes | ||||||||
Journal or Publication Title: | Industrial & Engineering Chemistry Research | ||||||||
Publisher: | American Chemical Society | ||||||||
ISSN: | 0888-5885 | ||||||||
Official Date: | 3 August 2022 | ||||||||
Dates: |
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Volume: | 61 | ||||||||
Number: | 30 | ||||||||
Page Range: | pp. 11181-11196 | ||||||||
DOI: | 10.1021/acs.iecr.2c00822 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Copyright Holders: | Copyright © 2022 The Authors. Published by American Chemical Society | ||||||||
Date of first compliant deposit: | 2 September 2022 | ||||||||
Date of first compliant Open Access: | 2 September 2022 | ||||||||
RIOXX Funder/Project Grant: |
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