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Light triggers the antiproliferative activity of naphthalimide-conjugated (η6-arene)ruthenium(II) complexes
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Bisceglie, Franco, Pelosi, Giorgio, Orsoni, Nicolò, Pioli, Marianna, Carcelli, Mauro, Pelagatti, Paolo, Pinelli, Silvana and Sadler, Peter J. (2022) Light triggers the antiproliferative activity of naphthalimide-conjugated (η6-arene)ruthenium(II) complexes. International Journal of Molecular Sciences, 23 (14). 7624. doi:10.3390/ijms23147624 ISSN 1422-0067.
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Official URL: https://doi.org/10.3390/ijms23147624
Abstract
We report the synthesis and characterization of three half-sandwich Ru(II) arene complexes [(η -arene)Ru(N,N')L][PF ] containing arene = p-cymene, N,N' = bipyridine, and L = pyridine meta- with methylenenaphthalimide (C1), methylene(nitro)naphthalimide (C2), or methylene(piperidinyl)naphthalimide (C3). The naphthalimide acts as an antenna for photoactivation. After 3 h of irradiation with blue light, the monodentate pyridyl ligand had almost completely dissociated from complex C3, which contains an electron donor on the naphthalimide ring, whereas only 50% dissociation was observed for C1 and C2. This correlates with the lower wavelength and strong absorption of C3 in this region of the spectrum (λ = 418 nm) compared with C1 and C2 (λ = 324 and 323 nm, respectively). All the complexes were relatively non-toxic towards A549 human lung cancer cells in the dark, but only complex C3 exhibited good photocytoxicity towards these cancer cells upon irradiation with blue light (IC = 10.55 ± 0.30 μM). Complex C3 has the potential for use in photoactivated chemotherapy (PACT).
Item Type: | Journal Article | ||||||
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Subjects: | Q Science > QD Chemistry | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Ruthenium compounds -- Synthesis, Aromatic compounds -- Synthesis, Cancer -- Chemotherapy, Photocatalysis, Chemistry, Organic | ||||||
Journal or Publication Title: | International Journal of Molecular Sciences | ||||||
Publisher: | M D P I AG | ||||||
ISSN: | 1422-0067 | ||||||
Official Date: | 10 July 2022 | ||||||
Dates: |
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Volume: | 23 | ||||||
Number: | 14 | ||||||
Article Number: | 7624 | ||||||
DOI: | 10.3390/ijms23147624 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 19 August 2022 | ||||||
Date of first compliant Open Access: | 19 August 2022 |
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