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ERK5 and the regulation of endothelial cell function
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Roberts, Owain Llyr, Holmes, Katherine, Müller, Jürgen, Cross, Darren A. E. and Cross, Michael J. (2009) ERK5 and the regulation of endothelial cell function. Biochemical Society Transactions, Vol.37 (Part 6). pp. 1254-1259. doi:10.1042/BST0371254 ISSN 0300-5127.
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Official URL: http://dx.doi.org/10.1042/BST0371254
Abstract
ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. it is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. in vitro studies have revealed that in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.
| Item Type: | Journal Article | ||||
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| Subjects: | Q Science > QD Chemistry | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Biochemical Society Transactions | ||||
| Publisher: | Portland Press Ltd | ||||
| ISSN: | 0300-5127 | ||||
| Official Date: | December 2009 | ||||
| Dates: |
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| Volume: | Vol.37 | ||||
| Number: | Part 6 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 1254-1259 | ||||
| DOI: | 10.1042/BST0371254 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), North West Cancer Research Fund, AstraZeneca |
Data sourced from Thomson Reuters' Web of Knowledge
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