The Library
Stress hormones: physiological stress and regulation of metabolism
Tools
Kyrou, Ioannis and Tsigos, Constantine (2009) Stress hormones: physiological stress and regulation of metabolism. Current Opinion in Pharmacology, Vol.9 (No.6). pp. 787-793. doi:10.1016/j.coph.2009.08.007
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.1016/j.coph.2009.08.007
Abstract
Stress, defined as a state of threatened homeostasis, mobilizes a complex spectrum of adaptive physiologic and behavioral responses that aim to re-establish the challenged body homeostasis. The hypothalamic-pituitary-ad renal (HPA) axis and the sympathetic nervous system (SNS) constitute the main effector pathways of the stress system, mediating its adaptive functions. In western societies, indices of stress correlate with increasing rates of both obesity and metabolic syndrome which have reached epidemic proportions. Recent data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate the stress system.
Item Type: | Journal Item | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RS Pharmacy and materia medica | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||
Journal or Publication Title: | Current Opinion in Pharmacology | ||||
Publisher: | Elsevier Science Ltd. | ||||
ISSN: | 1471-4892 | ||||
Official Date: | December 2009 | ||||
Dates: |
|
||||
Volume: | Vol.9 | ||||
Number: | No.6 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 787-793 | ||||
DOI: | 10.1016/j.coph.2009.08.007 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |