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Preterm birth therapies to target inflammation
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Pavlidis, Ioannis and Stock, Sarah J. (2022) Preterm birth therapies to target inflammation. The Journal of Clinical Pharmacology, 62 (S1). S79-S93. doi:10.1002/jcph.2107 ISSN 1552-4604.
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Official URL: https://doi.org/10.1002/jcph.2107
Abstract
Preterm birth (PTB; defined as delivery before 37 weeks of pregnancy) is the leading cause of morbidity and mortality in infants and children aged <5 years, conferring potentially devastating short‐ and long‐term complications. Despite extensive research in the field, there is currently a paucity of medications available for PTB prevention and treatment. Over the past few decades, inflammation in gestational tissues has emerged at the forefront of PTB pathophysiology. Even in the absence of infection, inflammation alone can prematurely activate the main components of parturition resulting in uterine contractions, cervical ripening and dilatation, membrane rupture, and subsequent PTB. Mechanistic studies have identified critical elements of the complex inflammatory molecular pathways involved in PTB. Here, we discuss therapeutic options that target such key mediators with an aim to prevent, postpone, or treat PTB. We provide an overview of more traditional therapies that are currently used or being tested in humans, and we highlight recent advances in preclinical studies introducing novel approaches with therapeutic potential. We conclude that urgent collaborative action is required to address the unmet need of developing effective strategies to tackle the challenge of PTB and its complications.
Item Type: | Journal Article | |||||||||
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Subjects: | R Medicine > RG Gynecology and obstetrics | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Premature labor -- Prevention, Uterus -- Diseases, Inflammation | |||||||||
Journal or Publication Title: | The Journal of Clinical Pharmacology | |||||||||
Publisher: | John Wiley & Sons, Inc. | |||||||||
ISSN: | 1552-4604 | |||||||||
Official Date: | 15 September 2022 | |||||||||
Dates: |
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Volume: | 62 | |||||||||
Number: | S1 | |||||||||
Page Range: | S79-S93 | |||||||||
DOI: | 10.1002/jcph.2107 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 26 October 2022 | |||||||||
Date of first compliant Open Access: | 28 October 2022 | |||||||||
RIOXX Funder/Project Grant: |
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