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Effective R2 relaxation rate, derived from dual-contrast fast-spin-echo MRI, enables detection of hemisphere differences in iron level and dopamine function in Parkinson’s disease and healthy individuals
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Luo, Jierong and Collingwood, Joanna F. (2022) Effective R2 relaxation rate, derived from dual-contrast fast-spin-echo MRI, enables detection of hemisphere differences in iron level and dopamine function in Parkinson’s disease and healthy individuals. Journal of Neuroscience Methods, 382 (109708). doi:10.1016/j.jneumeth.2022.109708 ISSN 0165-0270.
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WRAP-effective-R2-relaxation-rate-derived-dual-contrast fast-spin-echo-MRI-enables-detection-hemisphere-differences-iron-level-dopamine-function-Parkinson’s-disease-healthy-individuals-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (4Mb) | Preview |
Official URL: https://doi.org/10.1016/j.jneumeth.2022.109708
Abstract
Background: Clinical estimates of brain iron concentration are achievable with quantitative transverse relaxation rate R2, via time-consuming multiple spin-echo (SE) sequences. The objective of this study was to investigate whether quantitative iron-sensitive information may be derived from 3.0 T dual-contrast fast-spin-echo (FSE) sequences (typically employed in anatomical non-quantitative evaluations), as a routinely-collected alternative to evaluate iron levels in healthy (HC) and Parkinson’s disease (PD) brains.
New method: MRI 3.0 T FSE data from the Parkinson’s Progression Markers Initiative (PPMI) (12 PD, 12 age- and gender-matched HC subjects) were cross-sectionally and longitudinally evaluated. A new measure, ‘effective R2’, was calculated for bilateral subcortical grey matter (caudate nucleus, putamen, globus pallidus, red nucleus,
substantia nigra). Linear regression analysis was performed to correlate ‘effective R2’ with models of age-dependent brain iron concentration and striatal dopamine transporter (DaT) receptor binding ratio.
Results: Effective R2 was strongly correlated with estimated brain iron concentration. In PD, putaminal effective R2 difference was observed between the hemispheres contra-/ipsi-lateral to the predominantly symptomatic side at onset. This hemispheric difference was correlated with the putaminal DaT binding ratios in PD.
Comparison with existing method(s): Effective R2, derived from rapid dual-contrast FSE sequences, showed viability as an alternative to R2 from SE sequences. Linear correlation of effective R2 with estimated iron concentration was comparable to documented iron-dependent R2. The effective R2 correlation coefficient was consistent with theoretical R2 iron-dependence at 3.0 T.
Conclusions: Effective R2 has clinical potential as a fast quantitative method, as an alternative to R2, to aid evaluation of brain iron levels and DaT function.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine T Technology > T Technology (General) |
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Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | ||||||||
Library of Congress Subject Headings (LCSH): | Parkinson's disease, Metal ions -- Physiological effect, Iron -- Metabolism, Brain -- Metabolism, Magnetic resonance imaging -- Research, Brain -- Magnetic resonance imaging, Dopamine | ||||||||
Journal or Publication Title: | Journal of Neuroscience Methods | ||||||||
Publisher: | Elsevier BV | ||||||||
ISSN: | 0165-0270 | ||||||||
Official Date: | 1 December 2022 | ||||||||
Dates: |
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Volume: | 382 | ||||||||
Number: | 109708 | ||||||||
DOI: | 10.1016/j.jneumeth.2022.109708 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 27 September 2022 | ||||||||
Date of first compliant Open Access: | 28 September 2022 | ||||||||
Funder: | EPSRC, PPMI, University of Warwick | ||||||||
Grant number: | EP/V007688/1 | ||||||||
RIOXX Funder/Project Grant: |
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