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Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections : systematic review and meta-analysis
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Jullien, Sophie, Fitzgerald, Felicity, Keddie, Suzanne, Baerenbold, Oliver, Bassat, Quique, Bradley, John, Falconer, Jane, Fink, Colin, Keogh, Ruth, Hopkins, Heidi and Voice, Marie (2022) Diagnostic accuracy of multiplex respiratory pathogen panels for influenza or respiratory syncytial virus infections : systematic review and meta-analysis. BMC Infectious Diseases, 22 (1). 785. doi:10.1186/s12879-022-07766-9 ISSN 1471-2334.
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Official URL: https://doi.org/10.1186/s12879-022-07766-9
Abstract
Respiratory syncytial virus (RSV) and influenza viruses are important global causes of morbidity and mortality. We evaluated the diagnostic accuracy of the Luminex NxTAG respiratory pathogen panels (RPPs)™ (index) against other RPPs (comparator) for detection of RSV and influenza viruses. Studies comparing human clinical respiratory samples tested with the index and at least one comparator test were included. A random-effect latent class meta-analysis was performed to assess the specificity and sensitivity of the index test for RSV and influenza. Risk of bias was assessed using the QUADAS-2 tool and certainty of evidence using GRADE. Ten studies were included. For RSV, predicted sensitivity was 99% (95% credible interval [CrI] 96–100%) and specificity 100% (95% CrI 98–100%). For influenza A and B, predicted sensitivity was 97% (95% CrI 89–100) and 98% (95% CrI 88–100) respectively; specificity 100% (95% CrI 99–100) and 100% (95% CrI 99–100), respectively. Evidence was low certainty. Although index sensitivity and specificity were excellent, comparators’ performance varied. Further research with clear patient recruitment strategies could ascertain performance across different populations. Protocol Registration: Prospero CRD42021272062.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | BMC Infectious Diseases | ||||||
Publisher: | BioMed Central | ||||||
ISSN: | 1471-2334 | ||||||
Official Date: | 13 October 2022 | ||||||
Dates: |
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Volume: | 22 | ||||||
Number: | 1 | ||||||
Article Number: | 785 | ||||||
DOI: | 10.1186/s12879-022-07766-9 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 27 October 2022 | ||||||
Date of first compliant Open Access: | 27 October 2022 | ||||||
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