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A multi-centre study to risk stratify colorectal polyp surveillance patients utilising volatile organic compounds and faecal immunochemical test
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Chandrapalan, Subashini, Khasawneh, Farah, Singh, Baljit, Lewis, Stephen, Turvill, James, Persaud, Krishna and Arasaradnam, Ramesh P. (2022) A multi-centre study to risk stratify colorectal polyp surveillance patients utilising volatile organic compounds and faecal immunochemical test. Cancers, 14 (19). 4951. doi:10.3390/cancers14194951 ISSN 2072-6694.
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Official URL: https://doi.org/10.3390/cancers14194951
Abstract
(1) Background: The service capacity for colonoscopy remains constrained, and while efforts are being made to recover elective services, polyp surveillance remains a challenge. (2) Methods: This is a multi-centre study recruiting patients already on polyp surveillance. Stool and urine samples were collected for the faecal immunochemical test (FIT) and volatile organic compounds (VOC) analysis, and all participants then underwent surveillance colonoscopy. (3) Results: The sensitivity and specificity of VOC for the detection of a high-risk finding ((≥2 premalignant polyps including ≥1 advanced polyp or ≥5 premalignant polyps) were 0.94 (95% CI, 0.88 to 0.98) and 0.69 (95% CI, 0.64 to 0.75) respectively. For FIT, the sensitivity was (≥10 µg of haemoglobin (Hb) / g faeces) 0.54 (95% CI, 0.43 to 0.65) and the specificity was 0.79 (95% CI, 0.73 to 0.84). The probability reduction for having a high-risk finding following both negative VOC and FIT will be 24% if both tests are applied sequentially. (4) Conclusion: The diagnostic performance of VOC is superior to FIT for the detection of a high-risk finding. The performance further improves when VOC is applied together with FIT sequentially (VOC first and then FIT). VOC alone or the combination of VOC and FIT can be used as a triage tool for patients awaiting colonoscopy within a polyp surveillance population, especially in resource-constrained healthcare systems.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > QM Human anatomy R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Colonoscopy, Colon (Anatomy) -- Examination, Colon (Anatomy) -- Cancer -- Diagnosis, Intestinal polyps -- Diagnosis, Volatile organic compounds -- Health aspects, Medical screening | ||||||
| Journal or Publication Title: | Cancers | ||||||
| Publisher: | MDPI | ||||||
| ISSN: | 2072-6694 | ||||||
| Official Date: | 9 October 2022 | ||||||
| Dates: |
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| Volume: | 14 | ||||||
| Number: | 19 | ||||||
| Article Number: | 4951 | ||||||
| DOI: | 10.3390/cancers14194951 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 28 October 2022 | ||||||
| Date of first compliant Open Access: | 28 October 2022 | ||||||
| RIOXX Funder/Project Grant: |
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