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Pulmonary non-tuberculous mycobacteria in colonisation and disease in The Gambia
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Okoi, Catherine, Anderson, Suzanne T., Mulwa, Sarah, Worwui, Archibald, Antonio, Martin, Gehre, Florian and Adetifa, Ifedayo (2022) Pulmonary non-tuberculous mycobacteria in colonisation and disease in The Gambia. Scientific Reports, 12 (1). 19523. doi:10.1038/s41598-022-22777-x ISSN 2045-2322.
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Official URL: https://doi.org/10.1038/s41598-022-22777-x
Abstract
The clinical relevance of pulmonary non-tuberculous mycobacteria (PNTM) in The Gambia is unknown. The aim of this study was to estimate the prevalence of non-tuberculous mycobacteria (NTM) in colonisation, and the burden of clinically relevant pulmonary NTM (PNTM) disease in The Gambia. This was a cross-sectional study of the prevalence of NTM in participants aged ≥ 15 years, in a nationwide tuberculosis (TB) prevalence survey between December 2011 and January 2013. We enrolled 903 participants with suspected NTM and NTM cultures were confirmed by 16S rRNA gene sequencing analyses. We applied the American Thoracic Society/Infectious Disease Society of America (ATS/IDSA) diagnostic criteria to determine clinical relevance of NTM. A total of 575 participants had acid-fast bacilli (AFB) positive Mycobacterial Growth Indicator Tube (MGIT) cultures and 229 (39.8%) were NTM. M. avium complex was by far the most isolated NTM (71.0%), followed by M. fortuitum (9.5%) and M. nonchromogenicum (2.9%). Older participants (> 24 years old) were four times more likely to have NTM in their sputa. Only 20.5% (9/44) NTM cases met the ATS/IDSA criteria for NTM disease. This study provides important data on the prevalence of NTM in pulmonary samples of suspected TB cases with AFB positive cultures from a nationally representative population in The Gambia. Enhanced PNTM surveillance is recommended to better understand the contribution of NTM to pulmonary disease.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Scientific Reports | ||||||
Publisher: | Nature Publishing Group UK | ||||||
ISSN: | 2045-2322 | ||||||
Official Date: | 14 November 2022 | ||||||
Dates: |
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Volume: | 12 | ||||||
Number: | 1 | ||||||
Article Number: | 19523 | ||||||
DOI: | 10.1038/s41598-022-22777-x | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Re-use Statement: | ** From Springer Nature via Jisc Publications Router ** History: received 15-06-2022; registration 19-10-2022; accepted 19-10-2022; pub-electronic 14-11-2022; online 14-11-2022; collection 12-2022. ** Licence for this article: http://creativecommons.org/licenses/by/4.0/ ** Acknowledgements: Acknowledgements: We are grateful to staff and the participants of the Gambian Survey of Tuberculosis Prevalence, as well as staff of the molecular microbiology and Tuberculosis diagnostic and research laboratories at the Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, for their contributions to this study. Disclaimers: The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the institutions with which the authors are affiliated. | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
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