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A systems biology approach to understanding cis-regulatory module function
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Jeziorska, Danuta M., Jordan, Kate W. and Vance, Keith W. (2009) A systems biology approach to understanding cis-regulatory module function. Seminars in Cell and Developmental Biology, Vol.20 (No.7). pp. 856-862. doi:10.1016/j.semcdb.2009.07.007
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2009.07.007
Abstract
The genomic instructions used to regulate development are encoded within a set of functional DNA elements called cis-regulatory modules (CRMs). These elements determine the precise patterns of temporal and spatial gene expression. Here we summarize recent progress made towards cataloguing and characterizing the complete repertoire of CRMs. We describe CRMs as genomic information processing devices containing clusters of transcription factor binding sites and we position CRMs as nodes within large gene regulatory networks. We define CRM architecture and describe how these genomic elements process the information they encode to their target genes. Furthermore, we present an overview describing high-throughput techniques to identify CRMs genome wide and experimental methodologies to validate their function on a large scale. This review emphasizes the advantages and power of a systems biology approach which integrates computational and experimental technologies to further our understanding of CRM function. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) > Biological Sciences ( -2010) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Journal or Publication Title: | Seminars in Cell and Developmental Biology | ||||
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. | ||||
| ISSN: | 1084-9521 | ||||
| Official Date: | September 2009 | ||||
| Dates: |
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| Volume: | Vol.20 | ||||
| Number: | No.7 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | pp. 856-862 | ||||
| DOI: | 10.1016/j.semcdb.2009.07.007 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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