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Computational approaches to the integration of gene expression, ChIP-chip and sequence data in the inference of gene regulatory networks
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Cooke, Emma J., Savage, Richard S. and Wild, David L. (2009) Computational approaches to the integration of gene expression, ChIP-chip and sequence data in the inference of gene regulatory networks. Seminars in Cell and Developmental Biology, Vol.20 (No.7). pp. 863-868. doi:10.1016/j.semcdb.2009.08.004
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2009.08.004
Abstract
A major challenge in systems biology is the ability to model complex regulatory interactions, such as gene regulatory networks, and a number of computational approaches have been developed over recent years to address this challenge. This paper reviews a number of these approaches, with a focus on probabilistic graphical models and the integration of diverse data sets, such as gene expression and transcription factor binding site location and activity. (C) 2009 Elsevier Ltd. All rights reserved.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Research Centres > Molecular Organisation and Assembly in Cells (MOAC) Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre |
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| Journal or Publication Title: | Seminars in Cell and Developmental Biology | ||||
| Publisher: | Elsevier Science Ltd. / Academic Press Ltd. | ||||
| ISSN: | 1084-9521 | ||||
| Official Date: | September 2009 | ||||
| Dates: |
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| Volume: | Vol.20 | ||||
| Number: | No.7 | ||||
| Number of Pages: | 6 | ||||
| Page Range: | pp. 863-868 | ||||
| DOI: | 10.1016/j.semcdb.2009.08.004 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), EU Marie-Curie IRG Fellowship | ||||
| Grant number: | EP/F027400/1 (EPSRC), 46444 |
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