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Vaccine hesitancy prospectively predicts nocebo side-effects following COVID-19 vaccination
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Hoffman, Yaakov S. G., Levin, Yafit, Palgi, Yuval, Goodwin, Robin, Ben-Ezra, Menachem and Greenblatt-Kimron, Lee (2022) Vaccine hesitancy prospectively predicts nocebo side-effects following COVID-19 vaccination. Scientific Reports, 12 (1). 20018. doi:10.1038/s41598-022-21434-7 ISSN 2045-2322.
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WRAP-vaccine-hesitancy-prospectively-predicts-nocebo-side-effects-following-COVID-19-vaccination-Goodwin-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1326Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41598-022-21434-7
Abstract
The directionality between vaccine hesitancy and COVID-19 vaccine side-effects has not been hitherto examined. We hypothesized a nocebo effect, whereby vaccine hesitancy towards the second Pfizer vaccination dose predicts subsequent side-effects for a booster dose, beyond other effects. We expected these nocebo effects to be driven by (mis)information in males and prior experience in females. A representative sample of older adults (n = 756, mean age = 68.9 ± 3.43) were questioned in a typical cross-lagged design (wave 1 following a second Pfizer dose, wave 2 after their booster). As hypothesized, earlier vaccine hesitancy predicted subsequent booster side-effects for females (β = 0.10 p = 0.025, f 2 = 0.02) and males (β = 0.34, p < 0.001, f 2 = 0.16); effects were stronger in males (χ2Δ (1) = 4.34, p = 0.03). The (W1-to-W2) side-effect autoregression was stronger in females (β = .34, p < 0.001; males β = 0.18, p < 0.001), χ2Δ (1) = 26.86, p < 0.001. Results show that a quantifiable and meaningful portion of COVID-19 vaccine side-effects is predicted by vaccine hesitancy, demonstrating that side-effects comprise a psychosomatic nocebo component in vaccinated individuals. The data reveal distinct risk levels for future side-effects, suggesting the need to tailor public health messaging.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RA Public aspects of medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 Pandemic, 2020- , COVID-19 (Disease) -- Vaccination, Vaccine hesitancy , Nocebos (Medicine) | ||||||
| Journal or Publication Title: | Scientific Reports | ||||||
| Publisher: | Nature Publishing Group | ||||||
| ISSN: | 2045-2322 | ||||||
| Official Date: | 5 December 2022 | ||||||
| Dates: |
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| Volume: | 12 | ||||||
| Number: | 1 | ||||||
| Article Number: | 20018 | ||||||
| DOI: | 10.1038/s41598-022-21434-7 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 6 December 2022 | ||||||
| Date of first compliant Open Access: | 6 December 2022 | ||||||
| RIOXX Funder/Project Grant: |
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