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Preconception vitamin D level and in vitro fertilization : pregnancy outcome
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Hasan, Hayder A., Barber, Thomas M., Cheaib, Samer and Coussa, Ayla (2023) Preconception vitamin D level and in vitro fertilization : pregnancy outcome. Endocrine Practice, 29 (4). pp. 235-239. doi:10.1016/j.eprac.2023.01.005 ISSN 1530-891X.
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WRAP-preconception-vitamin-D-level-In-Vitro-Fertilization-pregnancy-outcome-Barber-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (262Kb) | Preview |
Official URL: https://doi.org/10.1016/j.eprac.2023.01.005
Abstract
Objective:
Vitamin D deficiency impairs female fertility and the success of in vitro fertilization (IVF). The recommended serum 25-hydroxyvitamin D (25(OH)D) level in IVF-conceived pregnancies is still debated. We aimed to explore the relationship of the preconception serum 25(OH)D level with pregnancy outcome following IVF treatment. We also explored the utility of the currently recommended serum 25(OH)D cutoff of ≥50 nmol/L for women undergoing IVF therapy.
Methods:
Retrospective cohort of women who had undergone IVF therapy. Of the women who started IVF therapy (n = 354), 218 completed the study. They were divided into 2 groups: (1) women who achieved a successful pregnancy (pregnant group, n = 160) and (2) those who did not achieve a successful pregnancy (nonpregnant group, n = 58). Preconception serum samples were analyzed for reproductive hormones, fasting glucose, insulin, and 25(OH)D levels.
Results:
Overall, the median (interquartile range) age, body mass index, and hemoglobin A1c level were 32 (6) years, 25.7 (7.4) kg/m2, and 5.2% (0.6%), respectively. The 25(OH)D level was significantly higher at preconception in the pregnant group (56.4 [21.4] vs 47.9 [29.16] for nonpregnant, P = .001). The preconception 25(OH)D level was a significant predictor of IVF outcome (B = 0.04; 95% CI, 1.01-1.06; P = .001), with greater IVF success associated with a serum 25(OH)D level of ≥50 nmol/L (odds ratio, 0.46; P = .01).
Conclusion:
Preconception 25(OH)D sufficiency (≥50 nmol/L) is associated with successful pregnancy outcome following IVF therapy.
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) | ||||||||
Journal or Publication Title: | Endocrine Practice | ||||||||
Publisher: | Elsevier Inc. on behalf of the AACE | ||||||||
ISSN: | 1530-891X | ||||||||
Official Date: | April 2023 | ||||||||
Dates: |
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Volume: | 29 | ||||||||
Number: | 4 | ||||||||
Page Range: | pp. 235-239 | ||||||||
DOI: | 10.1016/j.eprac.2023.01.005 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 6 February 2023 | ||||||||
Date of first compliant Open Access: | 6 February 2023 | ||||||||
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