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Trends in keratinocyte skin cancer incidence, mortality and burden of disease in 33 countries between 1990 and 2017
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Yang, Dorothy D., Borsky, Kim, Jani, Chinmay, Crowley, Conor, Rodrigues, Jeremy N., Matin, Rubeta N., Marshall, Dominic C., Salciccioli, Justin D., Shalhoub, Joseph and Goodall, Richard (2023) Trends in keratinocyte skin cancer incidence, mortality and burden of disease in 33 countries between 1990 and 2017. British Journal of Dermatology, 188 (2). pp. 237-246. doi:10.1093/bjd/ljac064 ISSN 1365-2133.
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Official URL: https://doi.org/10.1093/bjd/ljac064
Abstract
Background
Keratinocyte cancers (KCs) are the most common type of cancer in the White population worldwide, with associated high healthcare costs. Understanding the epidemiological trends for KCs, namely basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (SCCs), is required to assess burden of disease, project future trends and identify strategies for addressing this pressing global health issue.
Objectives
To report trends in BCC and SCC incidence, and SCC mortality and disability-adjusted life-years (DALYs).
Methods
An observational study of the Global Burden of Disease (GBD) database between 1990 and 2017 was performed. European Union countries and other selected high-income countries, including the UK and the USA, classified as having high-quality mortality data, were included. Annual age-standardized incidence rates (ASIRs), age-standardized death rates (ASDRs) and DALYs for each country were obtained from the GBD database. Trends were described using joinpoint regression analysis.
Results
Overall, 33 countries were included. For both BCC and SCC in 2015–2017, the highest ASIRs were observed in the USA and Australia. Males had higher ASIRs than females at the end of the observation period in all countries for SCC, and in all countries but two for BCC. In contrast, the highest ASDRs for SCC were observed in Australia and Latvia for males, and in Romania and Croatia for females. The highest DALYs for SCC for both sexes were seen in Australia and Romania. Over the observation period, there were more countries demonstrating decreasing trends in mortality than in incidence, and disparities were observed between which countries had comparatively high mortality rates and which had high incidence rates. Overall reductions in SCC DALYs were observed in 24 of 33 countries for males, and 25 countries for females.
Conclusions
Over the past 27 years, although trends in SCC incidence have risen in most countries, there is evidence that mortality rates have been decreasing. Burden of disease as assessed using DALYs has decreased in the majority of countries. Future work will explore potential explanatory factors for the observed disparity in trends in SCC incidence and mortality.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Basal cell carcinoma -- Epidemiology, Squamous cell carcinoma -- Epidemiology, Skin -- Cancer -- Epidemiology | ||||||||
Journal or Publication Title: | British Journal of Dermatology | ||||||||
Publisher: | Oxford University Press (OUP) | ||||||||
ISSN: | 1365-2133 | ||||||||
Official Date: | February 2023 | ||||||||
Dates: |
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Volume: | 188 | ||||||||
Number: | 2 | ||||||||
Page Range: | pp. 237-246 | ||||||||
DOI: | 10.1093/bjd/ljac064 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | This is a pre-copyedited, author-produced version of an article accepted for publication in British Journal of Dermatology following peer review. The version of record Dorothy D Yang, Kim Borsky, Chinmay Jani, Conor Crowley, Jeremy N Rodrigues, Rubeta N Matin, Dominic C Marshall, Justin D Salciccioli, Joseph Shalhoub, Richard Goodall, Trends in keratinocyte skin cancer incidence, mortality and burden of disease in 33 countries between 1990 and 2017, British Journal of Dermatology, Volume 188, Issue 2, February 2023, Pages 237–246, is available online at:https://doi.org/10.1093/bjd/ljac064 | ||||||||
Access rights to Published version: | Free Access (unspecified licence, 'bronze OA') | ||||||||
Date of first compliant deposit: | 17 March 2023 | ||||||||
Date of first compliant Open Access: | 26 October 2023 | ||||||||
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