The Library
Odor encoding by signals in the olfactory bulb
Tools
Verhagen, Justus V., Baker, Keeley L., Vasan, Ganesh, Pieribone, Vincent A. and Rolls, Edmund T. (2023) Odor encoding by signals in the olfactory bulb. Journal of Neurophysiology, 129 (2). pp. 431-444. doi:10.1152/jn.00449.2022 ISSN 0022-3077.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: https://doi.org/10.1152/jn.00449.2022
Abstract
To understand the operation of the olfactory system, it is essential to know how information is encoded in the olfactory bulb. We applied Shannon information theoretic methods to address this, with signals from up to 57 simultaneously optically imaged from pre-synaptic inputs in glomeruli in the mouse dorsal and lateral olfactory bulb, in response to six exemplar pure chemical odors. We discovered that, first, the tuning of these signals from glomeruli to a set of odors is remarkably broad with a mean sparseness of 0.83 and a mean signal correlation 0.64. Second, both of these factors contribute to the low information that is available from the responses of even populations of many tens of glomeruli, which was only 1.35 bits across 33 glomeruli on average, compared to the 2.58 bits required to perfectly encode these six odors. Third, although there is considerable interest in the possibility of temporal encoding of stimulus including odor identity, the amount of information in the temporal aspects of the pre-synaptic glomerular responses was low (mean 0.11 bits), and, importantly, was redundant with respect to the information available from the rates. Fourth, the information from simultaneously recorded glomeruli asymptotes very gradually and non-linearly, showing that glomeruli do not have independent responses. Fifth, the information from a population became available quite rapidly, within 100 ms of sniff onset, and the peak of the glomerular response was at 200 ms. Sixth, the information from the lateral olfactory bulb was not additive with that of the dorsal olfactory bulb.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Journal of Neurophysiology | ||||||||
Publisher: | American Physiological Society | ||||||||
ISSN: | 0022-3077 | ||||||||
Official Date: | 10 February 2023 | ||||||||
Dates: |
|
||||||||
Volume: | 129 | ||||||||
Number: | 2 | ||||||||
Page Range: | pp. 431-444 | ||||||||
DOI: | 10.1152/jn.00449.2022 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Copyright Holders: | Copyright © 2023 the American Physiological Society. |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |