The Library
Elevated circulating lactate levels and widespread expression of its cognate receptor, hydroxycarboxylic acid receptor 1 (HCAR1), in ovarian cancer
Tools
Kerslake, Rachel, Panfilov, Suzana, Mustafa, Nashrah, Hall, Marcia, Kyrou, Ioannis, Randeva, Harpal S., Karteris, Emmanouil and Godfrey, Richard (2023) Elevated circulating lactate levels and widespread expression of its cognate receptor, hydroxycarboxylic acid receptor 1 (HCAR1), in ovarian cancer. Journal of Clinical Medicine, 12 (1). 217. doi:10.3390/jcm12010217 ISSN 2077-0383.
|
PDF
WRAP-Elevated-circulating-lactate-levels-and-widespread-expression-of-its-cognate-receptor-hydroxycarboxylic-acid-receptor-1-HCAR1-in-ovarian-cancer-2023.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2612Kb) | Preview |
Official URL: https://doi.org/10.3390/jcm12010217
Abstract
Augmented glycolysis in cancer cells is a process required for growth and development. The Warburg effect provides evidence of increased glycolysis and lactic acid fermentation in cancer cells. The lactate end-product of glycolysis is receiving growing traction for its role as a cell signalling molecule. Ovarian cancer (OvCa) is also characterised by altered glucose metabolism. We aim to explore circulating lactate levels in patients with high-grade serous OvCa (HGSOC) and to elucidate the expression of the lactate receptor hydroxycarboxylic acid receptor 1 (HCAR1) in OvCa. HCAR1 expression was detected in patient biopsy cores using immunohistochemistry, while lactate was measured from whole blood with a Biosen-C line clinic measuring system. We noted significantly elevated lactate levels in OvCa patients (4.3 ± 1.9 mmol/L) compared with healthy controls (1.4 ± 0.6 mmol/L; < 0.0001), with an AUC of 0.96. The HCAR1 gene is overexpressed in OvCa compared to healthy controls ( < 0.001). Using an OvCa tissue microarray (>75% expression in 100 patients), high protein expression was also recorded across all epithelial OvCa subtypes and ovarian normal adjacent tissue (NAT). Lactate monitoring is a simple, cost-efficient test that can offer point-of-care results. Our data suggest that the potential of circulating lactate as a screening biomarker in OvCa merits further research attention.
Item Type: | Journal Article | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RG Gynecology and obstetrics |
|||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
SWORD Depositor: | Library Publications Router | |||||||||
Library of Congress Subject Headings (LCSH): | Lactates , Biopsy , G proteins -- Receptors, Ovaries -- Cancer | |||||||||
Journal or Publication Title: | Journal of Clinical Medicine | |||||||||
Publisher: | Royal College of Physicians | |||||||||
ISSN: | 2077-0383 | |||||||||
Official Date: | January 2023 | |||||||||
Dates: |
|
|||||||||
Volume: | 12 | |||||||||
Number: | 1 | |||||||||
Number of Pages: | 13 | |||||||||
Article Number: | 217 | |||||||||
DOI: | 10.3390/jcm12010217 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 14 February 2023 | |||||||||
Date of first compliant Open Access: | 15 February 2023 | |||||||||
RIOXX Funder/Project Grant: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year