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Platform trials for anaesthesia and perioperative medicine : a narrative review
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Myles, Paul S., Yeung, Joyce, Beattie, W. Scott, Ryan, Elizabeth G., Heritier, Stephane and McArthur, Colin J. (2023) Platform trials for anaesthesia and perioperative medicine : a narrative review. British Journal of Anaesthesia, 130 (6). pp. 677-686. doi:10.1016/j.bja.2022.10.030 ISSN 0007-0912.
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WRAP-Platform-trials-anaesthesia-perioperative-medicine-narrative-22.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (549Kb) | Preview |
Official URL: http://doi.org/10.1016/j.bja.2022.10.030
Abstract
Large randomised trials provide the most reliable evidence of effectiveness of new treatments in clinical practice. However, the time and resources required to complete such trials can be daunting. An overarching clinical trial platform focused on a single condition or type of surgery, aiming to compare several treatments, with an option to stop any or add in new treatment options, can provide greater efficiency. This has the potential to accelerate knowledge acquisition and identify effective, ineffective, or harmful treatments faster. The master protocol of the platform defines the study population(s) and standardised procedures. Ineffective or harmful treatments can be discarded or study drug dose modified during the life cycle of the trial. Other adaptive elements that can be modified include eligibility criteria, required sample size for any comparison(s), randomisation assignment ratio, and the addition of other promising treatment options. There are excellent opportunities for anaesthetists to establish platform trials in perioperative medicine. Platform trials are highly efficient, with the potential to provide quicker answers to important clinical questions that lead to improved patient care.
Item Type: | Journal Article | |||||||||
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Subjects: | R Medicine > RD Surgery | |||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
Library of Congress Subject Headings (LCSH): | Anesthesia, Cardiology, Anesthesiology, Clinical trials, Clinical medicine | |||||||||
Journal or Publication Title: | British Journal of Anaesthesia | |||||||||
Publisher: | Elsevier | |||||||||
ISSN: | 0007-0912 | |||||||||
Official Date: | June 2023 | |||||||||
Dates: |
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Volume: | 130 | |||||||||
Number: | 6 | |||||||||
Page Range: | pp. 677-686 | |||||||||
DOI: | 10.1016/j.bja.2022.10.030 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||
Date of first compliant deposit: | 10 February 2023 | |||||||||
Date of first compliant Open Access: | 28 November 2023 | |||||||||
RIOXX Funder/Project Grant: |
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