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Functional implications of Epstein-Barr virus lytic genes in carcinogenesis
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Yap, Lee Fah, Wong, Anna Kang Chee, Paterson, Ian C. and Young, Lawrence S. (2022) Functional implications of Epstein-Barr virus lytic genes in carcinogenesis. Cancers, 14 (23). 5780. doi:10.3390/cancers14235780 ISSN 2072-6694.
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Official URL: http://doi.org/10.3390/cancers14235780
Abstract
Epstein-Barr virus (EBV) is associated with a diverse range of tumors of both lymphoid and epithelial origin. Similar to other herpesviruses, EBV displays a bipartite life cycle consisting of latent and lytic phases. Current dogma indicates that the latent genes are key drivers in the pathogenesis of EBV-associated cancers, while the lytic genes are primarily responsible for viral transmission. In recent years, evidence has emerged to show that the EBV lytic phase also plays an important role in EBV tumorigenesis, and the expression of EBV lytic genes is frequently detected in tumor tissues and cell lines. The advent of next generation sequencing has allowed the comprehensive profiling of EBV gene expression, and this has revealed the consistent expression of several lytic genes across various types of EBV-associated cancers. In this review, we provide an overview of the functional implications of EBV lytic gene expression to the oncogenic process and discuss possible avenues for future investigations.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QR Microbiology > QR355 Virology R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | |||||||||
Library of Congress Subject Headings (LCSH): | Epstein-Barr virus, Epstein-Barr virus -- Genetic aspects, Viruses -- Reproduction, Viral carcinogenesis, Viral carcinogenesis -- Genetic aspects, Carcinogenesis, Carcinogenesis -- Genetic aspects, Gene expression | |||||||||
Journal or Publication Title: | Cancers | |||||||||
Publisher: | MDPI | |||||||||
ISSN: | 2072-6694 | |||||||||
Official Date: | 24 November 2022 | |||||||||
Dates: |
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Volume: | 14 | |||||||||
Number: | 23 | |||||||||
Article Number: | 5780 | |||||||||
DOI: | 10.3390/cancers14235780 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 6 February 2023 | |||||||||
Date of first compliant Open Access: | 6 February 2023 | |||||||||
RIOXX Funder/Project Grant: |
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