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JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos
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Karkali, Katerina, Saunders, Timothy E., Panayotou, George and Martín-Blanco, Enrique (2023) JNK signaling in pioneer neurons organizes ventral nerve cord architecture in Drosophila embryos. Nature Communications, 14 (1). 675. doi:10.1038/s41467-023-36388-1 ISSN 2041-1723.
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Official URL: https://doi.org/10.1038/s41467-023-36388-1
Abstract
Morphogenesis of the Central Nervous System (CNS) is a complex process that obeys precise architectural rules. Yet, the mechanisms dictating these rules remain unknown. Analyzing morphogenesis of the Drosophila embryo Ventral Nerve Cord (VNC), we observe that a tight control of JNK signaling is essential for attaining the final VNC architecture. JNK signaling in a specific subset of pioneer neurons autonomously regulates the expression of Fasciclin 2 (Fas 2) and Neurexin IV (Nrx IV) adhesion molecules, probably via the transcription factor zfh1. Interfering at any step in this cascade affects fasciculation along pioneer axons, leading to secondary cumulative scaffolding defects during the structural organization of the axonal network. The global disorder of architectural landmarks ultimately influences nervous system condensation. In summary, our data point to JNK signaling in a subset of pioneer neurons as a key element underpinning VNC architecture, revealing critical milestones on the mechanism of control of its structural organization.
Item Type: | Journal Article | |||||||||||||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QK Botany Q Science > QL Zoology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | |||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Central nervous system , Morphogenesis, Drosophila , Fruit-flies -- Morphogenesis, Protein kinases, Cellular signal transduction, Cell interaction | |||||||||||||||||||||
Journal or Publication Title: | Nature Communications | |||||||||||||||||||||
Publisher: | Nature Publishing Group | |||||||||||||||||||||
ISSN: | 2041-1723 | |||||||||||||||||||||
Official Date: | 7 February 2023 | |||||||||||||||||||||
Dates: |
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Volume: | 14 | |||||||||||||||||||||
Number: | 1 | |||||||||||||||||||||
Article Number: | 675 | |||||||||||||||||||||
DOI: | 10.1038/s41467-023-36388-1 | |||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||
Date of first compliant deposit: | 10 March 2023 | |||||||||||||||||||||
Date of first compliant Open Access: | 13 March 2023 | |||||||||||||||||||||
RIOXX Funder/Project Grant: |
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