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LIRcentral : a manually curated online database of experimentally validated functional LIR motifs
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Chatzichristofi, Agathangelos, Sagris, Vasileios, Pallaris, Aristos, Eftychiou, Marios, Kalvari, Ioanna, Price, Nicholas, Theodosiou, Theodosios, Iliopoulos, Ioannis, Nezis, Ioannis P. and Promponas, Vasilis J. (2023) LIRcentral : a manually curated online database of experimentally validated functional LIR motifs. Autophagy, 19 (12). pp. 3189-3200. doi:10.1080/15548627.2023.2235851 ISSN 1554-8627.
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Official URL: https://doi.org/10.1080/15548627.2023.2235851
Abstract
Several selective macroautophagy receptor and adaptor proteins bind members of the Atg8 (autophagy related 8) family using short linear motifs (SLiMs), most often referred to as Atg8-family interacting motifs (AIMs) or LC3-interacting regions (LIRs). AIM/LIR motifs have been extensively studied during the last fifteen years, since they can uncover the underlying biological mechanisms and possible substrates for this key catabolic process of eukaryotic cells. Prompted by the fact that experimental information regarding LIR motifs can be found scattered across heterogeneous literature resources, we have developed LIRcentral (https://lircentral.eu), a freely available online repository for user-friendly access to comprehensive, high-quality information regarding LIR motifs from manually curated publications. Herein, we describe the development of LIRcentral and showcase currently available data and features, along with our plans for the expansion of this resource. Information incorporated in LIRcentral is useful for accomplishing a variety of research tasks, including: (i) guiding wet biology researchers for the characterization of novel instances of LIR motifs, (ii) giving bioinformaticians/computational biologists access to high-quality LIR motifs for building novel prediction methods for LIR motifs and LIR containing proteins (LIRCPs) and (iii) performing analyses to better understand the biological importance/features of functional LIR motifs. We welcome feedback on the LIRcentral content and functionality by all interested researchers and anticipate this work to spearhead a community effort for sustaining this resource which will further promote progress in studying LIR motifs/LIRCPs.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
Library of Congress Subject Headings (LCSH): | Cell death, Protein-protein interactions, Cell receptors, Cellular control mechanisms | ||||||||||||
Journal or Publication Title: | Autophagy | ||||||||||||
Publisher: | Taylor & Francis | ||||||||||||
ISSN: | 1554-8627 | ||||||||||||
Book Title: | LIRcentral: a manually curated online database of experimentally validated functional LIR-motifs | ||||||||||||
Official Date: | 2023 | ||||||||||||
Dates: |
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Volume: | 19 | ||||||||||||
Number: | 12 | ||||||||||||
Page Range: | pp. 3189-3200 | ||||||||||||
DOI: | 10.1080/15548627.2023.2235851 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 3 March 2023 | ||||||||||||
Date of first compliant Open Access: | 23 August 2023 | ||||||||||||
RIOXX Funder/Project Grant: |
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