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The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome : emotion, memory, and action
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Rolls, Edmund T., Deco, Gustavo, Huang, Chu-Chung and Feng, Jianfeng (2023) The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome : emotion, memory, and action. Cerebral Cortex, 33 (2). pp. 330-356. doi:10.1093/cercor/bhac070 ISSN 1047-3211.
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WRAP-Human-orbitofrontal-cortex-anterior-cingulate-cortex-connectome-23.pdf - Accepted Version - Requires a PDF viewer. Download (1834Kb) | Preview |
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Official URL: http://doi.org/10.1093/cercor/bhac070
Abstract
The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior cingulate cortex are involved in reward processing and thereby in emotion but are also implicated in episodic memory. To understand these regions better, the effective connectivity between 360 cortical regions and 24 subcortical regions was measured in 172 humans from the Human Connectome Project and complemented with functional connectivity and diffusion tractography. The orbitofrontal cortex has effective connectivity from gustatory, olfactory, and temporal visual, auditory, and pole cortical areas. The orbitofrontal cortex has connectivity to the pregenual anterior and posterior cingulate cortex and hippocampal system and provides for rewards to be used in memory and navigation to goals. The orbitofrontal and pregenual anterior cortex have connectivity to the supracallosal anterior cingulate cortex, which projects to midcingulate and other premotor cortical areas and provides for action-outcome learning including limb withdrawal or flight or fight to aversive and nonreward stimuli. The lateral orbitofrontal cortex has outputs to language systems in the inferior frontal gyrus. The medial orbitofrontal cortex connects to the nucleus basalis of Meynert and the pregenual cingulate to the septum, and damage to these cortical regions may contribute to memory impairments by disrupting cholinergic influences on the neocortex and hippocampus.
Item Type: | Journal Article | |||||||||||||||||||||||||||||||||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||||||||||||||||||||||||||||||||||||||
Library of Congress Subject Headings (LCSH): | Frontal lobes, Prefrontal cortex, Frontal lobes -- Pathophysiology, Neuropsychology, Brain mapping, Neurosciences, Emotions | |||||||||||||||||||||||||||||||||||||||||||||
Journal or Publication Title: | Cerebral Cortex | |||||||||||||||||||||||||||||||||||||||||||||
Publisher: | Oxford University Press | |||||||||||||||||||||||||||||||||||||||||||||
ISSN: | 1047-3211 | |||||||||||||||||||||||||||||||||||||||||||||
Official Date: | 15 January 2023 | |||||||||||||||||||||||||||||||||||||||||||||
Dates: |
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Volume: | 33 | |||||||||||||||||||||||||||||||||||||||||||||
Number: | 2 | |||||||||||||||||||||||||||||||||||||||||||||
Page Range: | pp. 330-356 | |||||||||||||||||||||||||||||||||||||||||||||
DOI: | 10.1093/cercor/bhac070 | |||||||||||||||||||||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||||||||||||||||||||
Re-use Statement: | This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Edmund T Rolls, Gustavo Deco, Chu-Chung Huang, Jianfeng Feng, The human orbitofrontal cortex, vmPFC, and anterior cingulate cortex effective connectome: emotion, memory, and action, Cerebral Cortex, Volume 33, Issue 2, 15 January 2023, Pages 330–356 is available online at: http://doi.org/10.1093/cercor/bhac070 | |||||||||||||||||||||||||||||||||||||||||||||
Access rights to Published version: | Free Access (unspecified licence, 'bronze OA') | |||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant deposit: | 17 March 2023 | |||||||||||||||||||||||||||||||||||||||||||||
Date of first compliant Open Access: | 2 March 2024 | |||||||||||||||||||||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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