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Clostridioides difficile infection: traversing host–pathogen interactions in the gut
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Cheng, Jeffrey K. J. and Unnikrishnan, Meera (2023) Clostridioides difficile infection: traversing host–pathogen interactions in the gut. Microbiology, 169 (2). 001306. doi:10.1099/mic.0.001306 ISSN 1465-2080.
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Official URL: https://doi.org/10.1099/mic.0.001306
Abstract
C. difficile is the primary cause for nosocomial infective diarrhoea. For a successful infection, C. difficile must navigate between resident gut bacteria and the harsh host environment. The perturbation of the intestinal microbiota by broad-spectrum antibiotics alters the composition and the geography of the gut microbiota, deterring colonization resistance, and enabling C. difficile to colonize. This review will discuss how C. difficile interacts with and exploits the microbiota and the host epithelium to infect and persist. We provide an overview of C. difficile virulence factors and their interactions with the gut to aid adhesion, cause epithelial damage and mediate persistence. Finally, we document the host responses to C. difficile , describing the immune cells and host pathways that are associated and triggered during C. difficile infection.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
SWORD Depositor: | Library Publications Router | ||||||
Journal or Publication Title: | Microbiology | ||||||
Publisher: | Microbiology Society | ||||||
ISSN: | 1465-2080 | ||||||
Official Date: | 27 February 2023 | ||||||
Dates: |
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Volume: | 169 | ||||||
Number: | 2 | ||||||
Article Number: | 001306 | ||||||
DOI: | 10.1099/mic.0.001306 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 26 April 2023 | ||||||
Date of first compliant Open Access: | 26 April 2023 |
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