The Library
Contribution of Alzheimer's disease pathology to biological and clinical progression : a longitudinal study across two cohorts
Tools
Zhang, Wei, Wang, Hui‐Fu, Kuo, Kevin, Wang, Linbo, Li, Yuzhu, Yu, Jintai, Feng, Jianfeng and Cheng, Wei (2023) Contribution of Alzheimer's disease pathology to biological and clinical progression : a longitudinal study across two cohorts. Alzheimer's & Dementia, 19 (8). pp. 3602-3612. doi:10.1002/alz.12992 ISSN 1552-5260.
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://doi.org/10.1002/alz.12992
Abstract
Introduction:
Amyloid beta (Aβ) deposition, tau accumulation, and brain atrophy occurr in sequence, but the contribution of Alzheimer's disease (AD) pathology to biological and clinical progression remains unclear.
Methods:
We included 290 and 70 participants with longitudinal assessment on Aβ-positron emission tomography (PET), tau-PET, magnetic resonance imaging, and cognitive function from the Harvard Aging Brain Study (HABS) and Alzheimer's Disease Neuroimaging Initiative (ADNI) datasets, respectively. Partial least squares structural equation modeling (PLS-SEM) was used to determine the contribution of AD pathology to the biological and clinical longitudinal changes.
Results:
Imaging biomarkers and cognitive function were significantly associated in cross-sectional and longitudinal analyses. At the final time point, the percentage of variance explained by PLS-SEM was 27% for Aβ, 30% for tau (Aβ accounted for 61%), 29% for brain atrophy (tau accounted for 37%), and 37% for cognitive decline (brain atrophy accounted for 35%).
Discussion:
This study highlights distinctive contributing proportions of AD pathology to biological and clinical progression. Treatments targeting Aβ and tau may partially block AD progression.
Item Type: | Journal Article | ||||||||
---|---|---|---|---|---|---|---|---|---|
Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
Journal or Publication Title: | Alzheimer's & Dementia | ||||||||
Publisher: | Wiley | ||||||||
ISSN: | 1552-5260 | ||||||||
Official Date: | August 2023 | ||||||||
Dates: |
|
||||||||
Volume: | 19 | ||||||||
Number: | 8 | ||||||||
Page Range: | pp. 3602-3612 | ||||||||
DOI: | 10.1002/alz.12992 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |